nPOD Viral Working Group

nPOD has now assembled a “cloud” of investigators with diverse expertise, who are interested in collaborative studies, and is ready to take the nPOD research model to a higher level: the nPOD working groups. These groups are intended to collectively tackle key questions in diabetes research.

The nPOD viral working group (nPOD-V) represents a self-assembled collaborative effort with the goal of investigating the role of viruses in type 1 diabetes through the study of nPOD samples. An innovative concept implemented by the group is “real-time” data sharing, to help coordinate studies and inform strategy adjustments. This approach should accelerate the rate of discovery and maximize the potential for robust results. The premise underlying this collaboration, based on the nPOD research model and the concept of data sharing and collaboration promoted by the nPOD leadership, has been fully embraced by the nPOD-V investigators; we believe that this in itself represent a major step-forward and innovation in the study of complex questions in human disease.

Many studies have linked enterovirus infection to islet autoimmunity and diabetes. Yet, many questions remain about which virus serotypes are linked to T1D, what type of infection they cause, and how this may contribute to the autoimmune process leading to diabetes. Earlier studies from individual laboratories suffered from limitations with samples and reagents, and did not have access to the latest methodological advances. This collaborative effort recognizes those limitations, and addresses them with an integrated and multidisciplinary approach that includes many innovative and powerful technologies that have not been used before for studying viruses in type 1 diabetes. The availability of shared tissues from the same patients and their coordinated analysis provide unprecedented opportunity that investigations can be exhaustive and the most informative.

The precise identification of enterovirus serotypes associated with T1D and a better molecular characterization of the virus host interaction and relation to pancreas pathology could lead to the identification of novel, T1D-specific, biomarkers of infection and potentially novel therapeutic targets. If a virus plays a role in islet autoimmunity, a vaccine or drugs that target viral responses could perhaps become important therapeutic avenues for preventing the triggering of autoimmunity or its progression, reducing patient burden and potential exposure to immunosuppressive or immunomodulatory treatments which can be associated with significant side effects and long term concerns, especially when children are concerned.

List of nPOD-V Investigators:

Last NameFirst NameInstitution
AtkinsonMarkUniversity of Florida, nPOD
PuglieseAlbertoUniversity of Miami, nPOD
Campbell-ThompsonMarthaUniversity of Florida, nPOD
KaddisJohnCOH/Bechman Research Institute, nPOD
KusmartsevaIrinaUniversity of Florida, nPOD
YangMingderUniversity of Florida, nPOD
Clare-SalzlerMichaelUniversity of Florida
ChapmanNoraUniversity of Nebraska Medical Center
TracyStevenUniversity of Nebraska Medical Center
SmitheeShaneUniversity of Nebraska Medical Center
AlhazmiAbdulazizUniversity of Nebraska Medical Center
FriskGunUppsala University
AnagandulaMaheshUppsala University
SarimientoLuisUppsala University
GiepmansBenUniversity Medical Center Groningen
KalicharanRubyUniversity Medical Center Groningen
KuipersJeroenUniversity Medical Center Groningen
WoltersAnoukUniversity Medical Center Groningen
JelmerWillemsUniversity Medical Center Groningen
MorganNoelUniversity of Exeter
RichardsonSarahUniversity of Exeter
DyahalShalineeUniversity of Exeter (until2014)
RussellMarkUniversity of Exeter
LeetePiaUniversity of Exeter
NadlerJerryEastern Virginia Medical School
MorrisMargaretEastern Virginia Medical School
NyalwidheJuliusEastern Virginia Medical School
BurchTaynaEastern Virginia Medical School
von HerrathMatthiasLa Jolla Institute for Allergy and Immunology
Rodriguez-CalvoTeresaLa Jolla Institute for Allergy and Immunology
SabouriSomayehLa Jolla Institute for Allergy and Immunology
 Anquetil-BesnardFlorence La Jolla Institute for Allergy and Immunology
PlagnolVincentUniversity College London Genetics Institute
BreuerJudithUniversity College London
DepledgeDanielUniversity College London
DottaFrancescoUniversity of Siena
SebastianiGuidoUniversity of Siena
PattiAuroraUniversity of Siena
NigiLauraUniversity of Siena
VentrigliaGiulianaUniversity of Siena
MancarellaFrancescaUniversity of Siena
GerlingIvanUniversity of Tennessee Health Science Center
KakoolaDorothyUniversity of Tennessee Health Science Center
LenchikNataliyaUniversity of Tennessee Health Science Center
HyötyHeikkiUniversity of Tampere
LaihoJuttaUniversity of Tampere
OikarnenMaaritUniversity of Tampere
EizirikDecioUniversité libre de Bruxelles
OpDeBeeckAnneUniversité libre de Bruxelles
LloydRichardBaylor College of Medicine
PetrosinoJosephBaylor College of Medicine
HomannDirkUniversity of Colorado Denver
KentSallyUniversity of Massachusetts
SarkarSuparnaIcahn School of Medicine at Mount Sinai
TonioloAntonioUniversity of Insubria Medical School
GiananiRobertoUniversity of Chicago
PiemontiLorenzoSan Raffaele Scientific Institute
HorwitzMarcUniversity of British Columbia
MarjomakiVarpuUniversity of Jyväskylä
Flodström TullbergMalinKarolinska Institute
DomsgenErnaKarolinska Institute
LarssonPärKarolinska Institute