Dr. James received his bachelor’s degree in Chemical Engineering from the University of Colorado. He subsequently attended Washington State University, receiving his PhD in Biochemical Engineering in 2001. After completing an internship at Zymogenetics, he joined the Benaroya Research Institute as manager of the tetramer core and is currently a BRI assistant member. Dr. James is a member of the JDRF biomarker working group and co-leads the Immunology of Diabetes Society T Cell Workshop. Under the auspices of these groups, he leads biomarker development and validation projects aimed at improved disease staging of subjects who are diagnosed with type 1 diabetes. Dr. James leads several projects related to the role of epitope specific T cells in autoimmune disease. These include studies to investigate the role of protein modifications in neo-epitope formation and studies aimed at understanding how beta cell stress contributes to the breakdown of tolerance. Dr. James participates in several collaborative projects aimed at characterizing epitope specific T cells in autoimmune patients and at risk subjects, and clinical trial participants.