Dr. Pugliese, who joined the DRI in 1994, is dedicated to advancing type 1 diabetes research through scientific excellence, open collaboration, and the training of new investigators. For the last 25 years, he has studied type 1 diabetes from the preclinical period to the clinical diagnosis, and afterwards, in the setting of transplantation.
His work examines the role of genetic and immunological factors that lead to, or protect against, the development of type 1 diabetes. His studies have led to improved understanding of genetic and cellular mechanisms that regulate immunological self-tolerance (acceptance) specifically to molecules targeted in diabetes. Dr. Pugliese’s research has provided seminal contributions in type 1 diabetes genetics, immunology, pathology, and clinical trials.