nPOD. Beta Cell Development, Differentiation & Regeneration

Probing the normal human pancreatic and islet matrisome throughout development

Diabetes is a major world health problem, affecting millions of Americans, costing billions of dollars in treatment, and causing major late-stage health complications and death. Despite the promise of stem cell therapies for diabetes, the field of beta cell differentiation has not yet reached clinical application, mainly due to the lack of mature function and survival of the cells in vivo. A better understanding of the pancreatic and islet extracellular matrix (ECM), and what role ECM plays during beta cell development, function and maintenance may lead to a more translatable stem cell-derived beta cell product; as well as have important application in auto-and allo-islet transplantation.

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