Meeting Agenda – (Download PDF)
*All times are in Eastern Standard Time (EST).
ANNUAL MEETING RECURRING WEBINAR
(Same for all days)
You are invited to a Zoom@IU webinar.
https://iu.zoom.us/j/88640204409?pwd=YWNiUnFHcGVqNjdQbzdscU5oRmdPdz09
Password: 995906
Or Telephone:
Dial: +1 253 215 8782 (US Toll) or +1 346 248 7799 (US Toll)
Webinar ID: 886 4020 4409
International numbers available: https://iu.zoom.us/u/kbD6h30l0
01/30/2022
10:00 AM - 6:45 PM: Registration
Location: Serenoa
Hotel check-in will be at 4:00 pm.
12:00 PM - 12:15 PM: WELCOME - Opening Remarks
Opening Remarks By:
Mark Atkinson, PhD
nPOD Executive Director
The University of Florida
View Biography
Alberto Pugliese, MD
nPOD Co-Executive Director
University of Miami
View Biography
Carmella Evans-Molina, MD, PhD
nPOD Co-Executive Director
Indiana University
View Biography
Location: Atlantica Ballroom
12:15 PM - 1:45 PM: Cutting Edge Seminar I: Islet Cell Biology and Implications for Type 1 Diabetes
Co-Chairs: Emily Sims, MD and Ivan Gerling, PhD
Location: Atlantica Ballroom
Beta cell mitophagy and mitochondrial dysfunction in T1D (12:15 PM – 12:45 PM) – Virtual Presentation
Presenter:
Scott Soleimanpour, MD
University of Michigan Medicine
View Biography
Cellular Age Mosaicism (12:45 PM – 1:15 PM) – Virtual Presentation
Presenter:
Rafael Arrojo e Drigo, PhD
Vanderbilt University
Beta cell stress responses and senescence in T1D (1:15 PM – 1:45 PM) – Virtual Presentation
Presenter:
Peter Thompson, PhD
University of Manitoba
View Biography
1:45 PM - 2:15 PM: BREAK
2:30 PM - 2:45 PM: Discussion Session I: Islet Cell Biology and Implications for Type 1 Diabetes
Led by: Emily Sims, MD and Ivan Gerling, PhD
Location: Atlantica Ballroom
2:45 PM - 4:00 PM: Oral Abstracts I: Islet Biology
Co-Chairs: Christine Doucette, PhD and Joanna Almaça, PhD
Location: Atlantica Ballroom
Targeting glutamate receptors in human alpha cells restores glucagon secretion in type 1 diabetes (2:45 PM – 3:00 PM)
Presenter:
Julia Panzer, PhD
University of Miami
View Biography
View Abstract
12-Lipoxygenase Activates the integrated stress Presponse in Pancreatic Islets, Supresses PD-L1 Production, and promotes the development of T1D (3:00 PM – 3:15 PM) – Virtual Presentation
Presenter:
Abhishek Kulkarni, PhD
University of Chicago
View Abstract
Lessons on human beta cell biology from comprehensive methylome analysis (3:15 PM – 3:30 PM) – Virtual Presentation
Presenter:
Yuval Dor, PhD
The Hebrew University of Jerusalem
View Abstract
Elevated islet prohormone ratios as indicators of insulin dependency in islet transplant recipients (3:30 PM – 3:45 PM) – Virtual Presentation
Presenter:
Yi-Chun Chen, PhD
University of British Columbia
View Biography
View Abstract
Regulation of glucose metabolism by posttranslational modifications in Type 1 Diabetes (3:45 PM – 4:00 PM) – Virtual Presentation
Presenter:
Mark Mamula, PhD
Yale University School of Medicine
View Abstract
4:00 PM - 4:55 PM: nPOD Working Group Presentations: nPOD-Virus Group
Co-Chairs: Alberto Pugliese, MD and Dirk Homann MD, PhD
Location: Atlantica Ballroom
Modeling EV infection in pancreas slices (4:00 PM – 4:20 PM)
Presenter:
Mehdi Benkhala, PhD
La Jolla Institute for Immunology
View Biography
Gene expression and antiviral response profiles distinguish children who develop insulin or GAD-driven autoimmunity – the TEDDY study (4:20 PM – 4:40 PM)
Presenter:
Matti Nykter, PhD
Tampere University
View Abstract
Enterovirus Vaccination Trial and Teplizumab update (4:40 PM – 4:55 PM) – Virtual Presentation
Presenter:
Francisco Leon, MD, PhD
Provention
View Biography
4:55 PM - 5:20 PM: Discussion: nPOD-Virus Group
Co-Chairs: Alberto Pugliese, MD and Dirk Homann, MD, PhD
Location: Atlantica Ballroom
5:20 PM - 6:00 PM: BREAK
6:00 PM - 7:00 PM: RECEPTION (light hors d'oeuvres provided)
Location: Pristina and Verandina
7:00 PM - 7:45 PM: George Eisenbarth Memorial Lecture
Presenter:
Maki Nakayama, MD, PhD
University of Colorado School of Medicine
View Biography
Location: Atlantica Ballroom
7:45 PM: DINNER (on your own)
01/31/2022
7:00 AM - 4:30 PM: Registration
Location: Serenoa
Hotel check-in will begin at 4:00 pm.
7:00 AM - 8:00 AM: BREAKFAST
Location: Pristina and Verandina
8:00 AM - 8:45 AM: Oral abstracts II - Immunology
Co-Chairs: Todd Brusko, PhD and Mark Rigby, MD, PhD
Location: Atlantica Ballroom
Altered frequencies of TEMRA and CXCR3-positive cells among autoreactive CD4 T cells associated with recurrent islet autoimmunity in recipients of simultaneous pancreas-kidney transplants (8:00 AM – 8:15 AM)
Presenter:
Alberto Pugliese, MD
University of Miami
View Biography
View Abstract
Activation and trafficking of insulin-binding B cells to the pLN in nPOD donors (8:15 AM – 8:30 AM)
Presenter:
Mia Smith, PhD, DVM
Barbara Davis Center for Diabetes
View Abstract
Recognition of a splice variant neo-epitope by CD4+ T cells in subjects with Type 1 Diabetes (8:30 AM – 8:45 AM)
Presenter:
Eddie James, PhD
Benaroya Research Institute
View Biography
View Abstract
8:45 AM - 10:45 AM: Cutting Edge Seminar II: Autoimmunity/Pathogenesis
Co-Chairs: Jamie Felton, MD and Thomas Delong, PhD
Location: Atlantica Ballroom
Human tissue-resident memory T cells/pancreas (8:45 AM – 9:15 AM)
Presenter:
Donna Farber, PhD
Columbia University
View Biography
Emerging concepts around CD8 Biology (9:15 AM – 9:45 AM) – Virtual Presentation
Presenter:
Marcus Buggert, PhD
Karolinska Institute
View Biography
Development of adaptive immune responses in central and peripheral lymphoid tissues (9:45 AM – 10:15 AM) – Virtual Presentation
Presenter:
Maigan Brusko, PhD
University of Florida
Discovery of novel autoantigens (10:15 AM – 10:45 AM) – Virtual Presentation
Presenter:
Roberto Mallone, MD, PhD
Institut National de la Santé et de la Recherche Médicale
View Biography
10:45 AM - 11:00 AM: Discussion Session II: Autoimmunity/Pathogenesis in Type 1 Diabetes
Led by: Jamie Felton, MD and Thomas Delong, PhD
Location: Atlantica Ballroom
11:00 AM - 11:30 AM: BREAK
11:30 AM - 12:15 PM: Keynote Speaker: Seung Kim
New paradigms for islet genetics and transplantation tolerance: implications for diabetes research
Presenter:
Seung Kim, MD, PhD
Stanford University
Virtual Presentation
Location: Atlantica Ballroom
12:15 PM - 1:30 PM: LUNCH
Location: Pristina and Verandina
1:30 PM - 3:00 PM: CUTTING EDGE SEMINAR III: The Pancreas in T1D
Co-Chairs: Teresa Mastracci, PhD and Carmella Evans-Molina, MD, PhD
Location: Atlantica Ballroom
Pancreas imaging in T1D (1:30 PM – 2:00 PM)
Presenter:
Jack Virostko, PhD
Dell Medical School
View Biography
Exocrine pancreatic infiltrates (2:00 PM – 2:30 PM)
Presenter:
Kyle Gaulton, PhD
University of California San Diego
View Biography
Pancreas Vagal Neuroanatomy (2:30 PM – 3:00 PM) – Virtual Presentation
Presenter:
Martha Campbell-Thompson, DVM, PhD
University of Florida
View Biography
3:00 PM - 3:30 PM: Discussion Session III: Lessons from the Exocrine Pancreas
Led by: Teresa Mastracci, PhD and Carmella Evans-Molina, MD, PhD
Location: Atlantica Ballroom
3:30 PM - 3:45 PM: BREAK
3:45 PM - 4:30 PM: Oral Abstracts III: Novel Therapies
Co-Chairs: Jason Spaeth, PhD and Alice Long, PhD
Location: Atlantica Ballroom
Pre-clinical Evaluation of TYK2 Inhibitors as a Therapy for Type 1 Diabetes (3:45 PM – 4:00 PM) – Virtual Presentation
Presenter:
Farooq Syed, PhD
Indiana University School of Medicine
View Abstract
β-cell targeting of immune suppressive agonists in human pancreas tissue slices (4:00 PM – 4:15 PM)
Presenter:
Matthew Becker, PhD(c)
University of Florida
View Abstract
β-cell targeted Immune Suppressive PD-1 Bispecific Agonists – a Novel Approach to Treat Type 1 Diabetes (4:15 PM – 4:30 PM) – Virtual Presentation
Presenter:
Giovanni Bossi, PhD
Immunocore ltd
View Biography
View Abstract
4:30 PM - 7:00 PM: Free Time/Networking
5:00 PM - 6:00 PM: Virtual Poster Presentation
View virtual posters and videos here.
Link: https://tinyurl.com/2bdvcvv9
Meeting ID: 824 5897 3710
Password: 941422
7:00 PM - 9:00 PM: Dinner & Awards Ceremony
Location: Verandina
02/01/2022
7:00 AM - 8:00 AM: BREAKFAST
Location: Pristina and Verandina
8:00 AM - 9:30 AM: Cutting Edge Seminar IV: Alpha Cells
Co-Chairs: Klaus Kaestner, PhD and Clayton Mathews, PhD
Location: Atlantica Ballroom
ZT-01, a First-in-class SSTR2 Antagonist to Prevent Hypoglycemia in Insulin Dependent Diabetes (8:00 AM – 8:30 AM) – Virtual Presentation
Presenter:
Richard Liggins, PhD
Zucara Therapeutics
Targeting GIP/GLP-2 Receptors to Prevent Hypoglycemia in Type 1 Diabetes (8:30 AM – 9:00 AM) – Virtual Presentation
Presenter:
Filip Knop, MD, PhD
Gentofte Hospital, University of Copenhagen
Alpha Cell Dysfunction Precedes Beta Cell Loss in T1D (9:00 AM – 9:30 AM) – Virtual Presentation
Presenter:
Doris Stoffers, MD, PhD
University of Pennsylvania
9:30 AM - 10:00 AM: Discussion Session IV: Alpha Cells
Led by: Klaus Kaestner, PhD and Clayton Mathews, PhD
Location: Atlantica Ballroom
10:00 AM - 10:30 AM: BREAK
10:30 AM - 11:30 AM: nPOD Working Group Presentations: nPOD-Slice Group
Co-Chairs: Alberto Pugliese, MD and Edward Phelps, PhD
Location: Atlantica Ballroom
Changes in the human microvasculature during T1D (10:30 AM – 10:50 AM)
Presenter:
Joana Almaça, PhD
University of Miami Miller School of Medicine
View Biography
Characterizing endocrine cell ross talk in human islets in situ during T1D progression (10:50 AM – 11:10 AM)
Presenter:
Richard Benninger, PhD
University of Colorado Denver
View Biography
Developing Kinase Inhibitors of IRE1α to Treat Diabetes (11:10 AM – 11:30 AM) – Virtual Presentation
Presenter:
Feroz Papa, MD, PhD
University of California San Francisco
View Biography
11:30 AM - 12:15 PM: Oral Abstracts IV: Pathogenesis
Chair: Lori Sussel, PhD and Esther Latres, PhD
Location: Atlantica Ballroom
Type 2 diabetes-associated TCF7L2 genetic variants and African American race protect from loss of insulin containing islets in type 1 diabetes (11:30 AM – 11:45 AM)
Presenter:
Maria Redondo, MD, PhD
Baylor College of Medicine, Texas Children’s Hospital
View Biography
View Abstract
Single nucleus-resolved chromatin accessibility profiles of pancreatic islet cells (11:45 PM – 12:00 PM)
Presenter:
Michelle Lee
University of Pennsylvania
View Abstract
Humoral Factors and Circulating Extracellular Vesicles in Type 1 Diabtes Induce Beta Cell Cytoxicity (12:00 AM – 12:15 PM) – Virtual Presentation
Presenter:
Nagesha Guthal Kondegowda, PhD
Arthur Riggs Diabetes and Metabolism Institute, City of Hope National Medical Center
View Biography
View Abstract
12:15 PM - 1:30 PM: LUNCH
Location: Pristina and Verandina
1:30 PM - 3:30 PM: Shark Tank
Sharks: Desmond Schatz, MD, Chantal Mathieu, MD (Virtual), Jessica Dunne, PhD, and Bart Roep, PhD (Virtual)
Location: Atlantica Ballroom
What do single autoantibody positive tell us in terms of disease prediction? (1:30 PM – 1:50 PM) – Virtual Presentation
Presenter:
Ezio Bonifactio, PhD
Technische Universität Dresden
What do metabolic data from clinical cohorts tell us? (1:50 PM – 2:10 PM)
Presenter:
Maria Redondo, MD, PhD
Baylor College of Medicine, Texas Children’s Hospital
View Biography
Is autoantibody positivity important for islet MHC expression? (2:10 PM – 2:30 PM)
Presenter:
Estefania Quesada-Masachs, MD, PhD
La Jolla Institute for Immunology
View Biography
Dealing with false positives and overlap forms of diabetes (2:30 PM – 2:50 PM) – Virtual Presentation
Presenter:
Angus Jones, PhD
University of Exeter College of Medicine and Health
View Biography
Are there unique features in single autoantibody positive pancreas? (2:50 PM – 3:10 PM)
Presenter:
Mark Atkinson, PhD
University of Florida
Open Discussion (3:10 PM – 3:30 PM)
3:30 PM - 3:45 PM: BREAK
3:45 PM - 4:45 PM: Hot Topics in Autoimmunity
Co-Chairs: Simi Ahmed, PhD and Eddie James, PhD
Responder and nonresponder analysis in T1D prevention trials (3:45 PM – 4:15 PM)
Presenter:
Alice Long, PhD
Benaroya Research Institute
View Biography
Immune signatures in T1D (4:15 PM – 4:45 PM)
Presenter:
Eoin Mckinney, MD (Virtual) and Dirk Homann, MD
University of Cambridge & Mount Sinai
View Dirk Homann’s Biography
4:45 PM - 5:15 PM: Discussion Session: Hot Topics in Autoimmunity
Led by: Simi Ahmed, PhD and Eddie James, PhD
Location: Atlantica Ballroom
5:15 PM - 6:00 PM: FREE TIME/NETWORKING
6:00 PM - 8:00 PM: Poster Session (heavy hors d'oeuvres provided)
Sponsored by Provention
Location: Pristina, Verandina, and Solaria
In-person attendance only
8:00 PM: DINNER (on your own)
02/02/2022
7:00 AM - 8:45 AM: Breakfast & Checkout
Hotel checkout is 12 PM.
If checking out today, please bring luggage to the registration table for the remainder of the meeting.
Note: Breakfast will only be served from 7:00 AM – 8:00 AM.
8:45 AM - 10:15 AM: Cutting Edge Seminar V: Emerging Technologies
Co-Chairs: Amelia Linnemann, PhD and Holger Russ, PhD
Location: Atlantica Ballroom
Update from the Beta Cell Consortium (8:45 AM – 9:15 AM)
Presenter:
Kate White, PhD
University of Southern California
View Biography
Islet function: A splice of life (9:15 AM – 9:45 AM)
Presenter:
Lori Sussell, PhD
University of Colorado
Islet on a chip (9:45 AM -10:15 AM)
Presenter:
Ashu Agarwal, PhD
University of Miami
View Biography
10:15 AM - 10:45 AM: Discussion Session V: Emerging Technologies
Led by: Amelia Linnemann, PhD and Holger Russ, PhD
Location: Atlantica Ballroom
10:45 AM - 11:15 AM: BREAK
11:15 AM - 12:00 PM: Open-mic discussion session: What did we miss and where should we go?
Led by: Alberto Pugliese, MD and Carmella Evans-Molina MD, PhD, and Mark Atkinson PhD