Meeting Agenda – (Download PDF)

*All times are in Eastern Standard Time (EST).

ANNUAL MEETING RECURRING WEBINAR

(Same for all days)
You are invited to a Zoom@IU webinar.
https://iu.zoom.us/j/88640204409?pwd=YWNiUnFHcGVqNjdQbzdscU5oRmdPdz09
Password: 995906

Or Telephone:
Dial: +1 253 215 8782 (US Toll) or +1 346 248 7799 (US Toll)
Webinar ID: 886 4020 4409
International numbers available: https://iu.zoom.us/u/kbD6h30l0

01/30/2022

10:00 AM - 6:45 PM: Registration

Location: Serenoa

Hotel check-in will be at 4:00 pm. 

12:00 PM - 12:15 PM: WELCOME - Opening Remarks

Opening Remarks By:

Mark Atkinson, PhD
nPOD Executive Director
The University of Florida
View Biography

Alberto Pugliese, MD
nPOD Co-Executive Director
University of Miami
View Biography

Carmella Evans-Molina, MD, PhD
nPOD Co-Executive Director
Indiana University
View Biography

Location: Atlantica Ballroom

12:15 PM - 1:45 PM: Cutting Edge Seminar I: Islet Cell Biology and Implications for Type 1 Diabetes

Co-Chairs: Emily Sims, MD and Ivan Gerling, PhD

Location: Atlantica Ballroom


Beta cell mitophagy and mitochondrial dysfunction in T1D (12:15 PM – 12:45 PM) – Virtual Presentation

Presenter:
Scott Soleimanpour, MD

University of Michigan Medicine
View Biography


Cellular Age Mosaicism (12:45 PM – 1:15 PM) – Virtual Presentation

Presenter:
Rafael Arrojo e Drigo, PhD

Vanderbilt University


Beta cell stress responses and senescence in T1D (1:15 PM – 1:45 PM) – Virtual Presentation

Presenter:
Peter Thompson, PhD

University of Manitoba
View Biography


1:45 PM - 2:15 PM: BREAK

2:30 PM - 2:45 PM: Discussion Session I: Islet Cell Biology and Implications for Type 1 Diabetes

Led by: Emily Sims, MD and Ivan Gerling, PhD

Location: Atlantica Ballroom

2:45 PM - 4:00 PM: Oral Abstracts I: Islet Biology

Co-Chairs: Christine Doucette, PhD and Joanna Almaça, PhD

Location: Atlantica Ballroom


Targeting glutamate receptors in human alpha cells restores glucagon secretion in type 1 diabetes (2:45 PM – 3:00 PM)

Presenter:
Julia Panzer, PhD

University of Miami
View Biography
View Abstract


12-Lipoxygenase Activates the integrated stress Presponse in Pancreatic Islets, Supresses PD-L1 Production, and promotes the development of T1D (3:00 PM – 3:15 PM) – Virtual Presentation

Presenter:
Abhishek Kulkarni, PhD

University of Chicago
View Abstract


Lessons on human beta cell biology from comprehensive methylome analysis (3:15 PM – 3:30 PM) – Virtual Presentation

Presenter:
Yuval Dor, PhD

The Hebrew University of Jerusalem
View Abstract


Elevated islet prohormone ratios as indicators of insulin dependency in islet transplant recipients (3:30 PM – 3:45 PM) – Virtual Presentation

Presenter:
Yi-Chun Chen, PhD

University of British Columbia
View Biography
View Abstract


Regulation of glucose metabolism by posttranslational modifications in Type 1 Diabetes (3:45 PM – 4:00 PM) – Virtual Presentation

Presenter:
Mark Mamula, PhD

Yale University School of Medicine
View Abstract


4:00 PM - 4:55 PM: nPOD Working Group Presentations: nPOD-Virus Group

Co-Chairs: Alberto Pugliese, MD and Dirk Homann MD, PhD

Location: Atlantica Ballroom


Modeling EV infection in pancreas slices (4:00 PM – 4:20 PM)

Presenter:
Mehdi Benkhala, PhD

La Jolla Institute for Immunology
View Biography


Gene expression and antiviral response profiles distinguish children who develop insulin or GAD-driven autoimmunity – the TEDDY study (4:20 PM – 4:40 PM)

Presenter:
Matti Nykter, PhD

Tampere University
View Abstract


Enterovirus Vaccination Trial and Teplizumab update (4:40 PM – 4:55 PM) – Virtual Presentation

Presenter:
Francisco Leon, MD, PhD

Provention
View Biography

 

4:55 PM - 5:20 PM: Discussion: nPOD-Virus Group

Co-Chairs: Alberto Pugliese, MD and Dirk Homann, MD, PhD

Location: Atlantica Ballroom

5:20 PM - 6:00 PM: BREAK

6:00 PM - 7:00 PM: RECEPTION (light hors d'oeuvres provided)

Location: Pristina and Verandina

7:00 PM - 7:45 PM: George Eisenbarth Memorial Lecture

Presenter:
Maki Nakayama, MD, PhD

University of Colorado School of Medicine
View Biography

Location: Atlantica Ballroom

7:45 PM: DINNER (on your own)

01/31/2022

7:00 AM - 4:30 PM: Registration

Location: Serenoa

Hotel check-in will begin at 4:00 pm.

7:00 AM - 8:00 AM: BREAKFAST

Location: Pristina and Verandina

8:00 AM - 8:45 AM: Oral abstracts II - Immunology

Co-Chairs: Todd Brusko, PhD and Mark Rigby, MD, PhD

Location: Atlantica Ballroom


Altered frequencies of TEMRA and CXCR3-positive cells among autoreactive CD4 T cells associated with recurrent islet autoimmunity in recipients of simultaneous pancreas-kidney transplants (8:00 AM – 8:15 AM)

Presenter:
Alberto Pugliese, MD

University of Miami
View Biography
View Abstract


Activation and trafficking of insulin-binding B cells to the pLN in nPOD donors (8:15 AM – 8:30 AM)

Presenter:
Mia Smith, PhD, DVM

Barbara Davis Center for Diabetes
View Abstract


Recognition of a splice variant neo-epitope by CD4+ T cells in subjects with Type 1 Diabetes (8:30 AM – 8:45 AM)

Presenter:
Eddie James, PhD
Benaroya Research Institute
View Biography
View Abstract

8:45 AM - 10:45 AM: Cutting Edge Seminar II: Autoimmunity/Pathogenesis

Co-Chairs: Jamie Felton, MD and Thomas Delong, PhD
Location: Atlantica Ballroom


Human tissue-resident memory T cells/pancreas (8:45 AM – 9:15 AM)

Presenter:
Donna Farber, PhD

Columbia University
View Biography


Emerging concepts around CD8 Biology (9:15 AM – 9:45 AM) – Virtual Presentation

Presenter:
Marcus Buggert, PhD

Karolinska Institute
View Biography


Development of adaptive immune responses in central and peripheral lymphoid tissues  (9:45 AM – 10:15 AM) – Virtual Presentation

Presenter:
Maigan Brusko, PhD

University of Florida


Discovery of novel autoantigens (10:15 AM – 10:45 AM) – Virtual Presentation

Presenter:
Roberto Mallone, MD, PhD

Institut National de la Santé et de la Recherche Médicale
View Biography

10:45 AM - 11:00 AM: Discussion Session II: Autoimmunity/Pathogenesis in Type 1 Diabetes

Led by: Jamie Felton, MD and Thomas Delong, PhD

Location: Atlantica Ballroom

11:00 AM - 11:30 AM: BREAK

11:30 AM - 12:15 PM: Keynote Speaker: Seung Kim

New paradigms for islet genetics and transplantation tolerance: implications for diabetes research

Presenter: 
Seung Kim, MD, PhD

Stanford University
Virtual Presentation

Location: Atlantica Ballroom

12:15 PM - 1:30 PM: LUNCH

Location: Pristina and Verandina

1:30 PM - 3:00 PM: CUTTING EDGE SEMINAR III: The Pancreas in T1D

Co-Chairs: Teresa Mastracci, PhD and Carmella Evans-Molina, MD, PhD

Location: Atlantica Ballroom


Pancreas imaging in T1D (1:30 PM – 2:00 PM)

Presenter:
Jack Virostko, PhD

Dell Medical School
View Biography


Exocrine pancreatic infiltrates (2:00 PM – 2:30 PM)

Presenter:
Kyle Gaulton, PhD
University of California San Diego
View Biography


Pancreas Vagal Neuroanatomy (2:30 PM – 3:00 PM) – Virtual Presentation

Presenter:
Martha Campbell-Thompson, DVM, PhD

University of Florida
View Biography


3:00 PM - 3:30 PM: Discussion Session III: Lessons from the Exocrine Pancreas

Led by: Teresa Mastracci, PhD and Carmella Evans-Molina, MD, PhD

Location: Atlantica Ballroom

3:30 PM - 3:45 PM: BREAK

3:45 PM - 4:30 PM: Oral Abstracts III: Novel Therapies

Co-Chairs: Jason Spaeth, PhD and Alice Long, PhD

Location: Atlantica Ballroom


Pre-clinical Evaluation of TYK2 Inhibitors as a Therapy for Type 1 Diabetes (3:45 PM – 4:00 PM) – Virtual Presentation

Presenter:
Farooq Syed, PhD

Indiana University School of Medicine
View Abstract


β-cell targeting of immune suppressive agonists in human pancreas tissue slices (4:00 PM – 4:15 PM)

Presenter:
Matthew Becker, PhD(c)
University of Florida
View Abstract


β-cell targeted Immune Suppressive PD-1 Bispecific Agonists – a Novel Approach to Treat Type 1 Diabetes (4:15 PM – 4:30 PM) – Virtual Presentation

Presenter:
Giovanni Bossi, PhD

Immunocore ltd
View Biography
View Abstract


4:30 PM - 7:00 PM: Free Time/Networking

5:00 PM - 6:00 PM: Virtual Poster Presentation

View virtual posters and videos here.

Link: https://tinyurl.com/2bdvcvv9 
Meeting ID: 824 5897 3710
Password: 941422 

7:00 PM - 9:00 PM: Dinner & Awards Ceremony

Location: Verandina

02/01/2022

7:00 AM - 8:00 AM: BREAKFAST

Location: Pristina and Verandina

8:00 AM - 9:30 AM: Cutting Edge Seminar IV: Alpha Cells

Co-Chairs: Klaus Kaestner, PhD and Clayton Mathews, PhD

Location: Atlantica Ballroom


ZT-01, a First-in-class SSTR2 Antagonist to Prevent Hypoglycemia in Insulin Dependent Diabetes (8:00 AM – 8:30 AM) – Virtual Presentation

Presenter:
Richard Liggins, PhD

Zucara Therapeutics


Targeting GIP/GLP-2 Receptors to Prevent Hypoglycemia in Type 1 Diabetes (8:30 AM – 9:00 AM) – Virtual Presentation

Presenter:
Filip Knop, MD, PhD
Gentofte Hospital, University of Copenhagen


Alpha Cell Dysfunction Precedes Beta Cell Loss in T1D (9:00 AM – 9:30 AM) – Virtual Presentation

Presenter:
Doris Stoffers, MD, PhD

University of Pennsylvania


9:30 AM - 10:00 AM: Discussion Session IV: Alpha Cells

Led by: Klaus Kaestner, PhD and Clayton Mathews, PhD

Location: Atlantica Ballroom

10:00 AM - 10:30 AM: BREAK

10:30 AM - 11:30 AM: nPOD Working Group Presentations: nPOD-Slice Group

Co-Chairs: Alberto Pugliese, MD and Edward Phelps, PhD

Location: Atlantica Ballroom


Changes in the human microvasculature during T1D (10:30 AM – 10:50 AM)

Presenter:
Joana Almaça, PhD

University of Miami Miller School of Medicine
View Biography


Characterizing endocrine cell ross talk in human islets in situ during T1D progression (10:50 AM – 11:10 AM)

Presenter:
Richard Benninger, PhD

University of Colorado Denver
View Biography


Developing Kinase Inhibitors of IRE1α to Treat Diabetes (11:10 AM – 11:30 AM) – Virtual Presentation

Presenter:
Feroz Papa, MD, PhD

University of California San Francisco
View Biography

11:30 AM - 12:15 PM: Oral Abstracts IV: Pathogenesis

Chair: Lori Sussel, PhD and Esther Latres, PhD

Location: Atlantica Ballroom


Type 2 diabetes-associated TCF7L2 genetic variants and African American race protect from loss of insulin containing islets in type 1 diabetes (11:30 AM – 11:45 AM)

Presenter:
Maria Redondo, MD, PhD
Baylor College of Medicine, Texas Children’s Hospital
View Biography
View Abstract


Single nucleus-resolved chromatin accessibility profiles of pancreatic islet cells (11:45 PM – 12:00 PM)

Presenter:
Michelle Lee

University of Pennsylvania
View Abstract


Humoral Factors and Circulating Extracellular Vesicles in Type 1 Diabtes Induce Beta Cell Cytoxicity (12:00 AM – 12:15 PM) – Virtual Presentation

Presenter:
Nagesha Guthal Kondegowda, PhD

Arthur Riggs Diabetes and Metabolism Institute, City of Hope National Medical Center
View Biography
View Abstract


12:15 PM - 1:30 PM: LUNCH

Location: Pristina and Verandina

1:30 PM - 3:30 PM: Shark Tank

Sharks: Desmond Schatz, MD, Chantal Mathieu, MD (Virtual), Jessica Dunne, PhD, and Bart Roep, PhD (Virtual)

Location: Atlantica Ballroom 


What do single autoantibody positive tell us in terms of disease prediction? (1:30 PM – 1:50 PM) – Virtual Presentation

Presenter:
Ezio Bonifactio, PhD

Technische Universität Dresden


What do metabolic data from clinical cohorts tell us? (1:50 PM – 2:10 PM)

Presenter:
Maria Redondo, MD, PhD

Baylor College of Medicine, Texas Children’s Hospital
View Biography


Is autoantibody positivity important for islet MHC expression? (2:10 PM – 2:30 PM)

Presenter:
Estefania Quesada-Masachs, MD, PhD

La Jolla Institute for Immunology
View Biography


Dealing with false positives and overlap forms of diabetes (2:30 PM – 2:50 PM) – Virtual Presentation

Presenter:
Angus Jones, PhD

University of Exeter College of Medicine and Health
View Biography


Are there unique features in single autoantibody positive pancreas? (2:50 PM – 3:10 PM)

Presenter:
Mark Atkinson, PhD

University of Florida


Open Discussion (3:10 PM – 3:30 PM)


3:30 PM - 3:45 PM: BREAK

3:45 PM - 4:45 PM: Hot Topics in Autoimmunity

Co-Chairs: Simi Ahmed, PhD and Eddie James, PhD


Responder and nonresponder analysis in T1D prevention trials (3:45 PM – 4:15 PM)

Presenter:
Alice Long, PhD
Benaroya Research Institute
View Biography


Immune signatures in T1D (4:15 PM – 4:45 PM)

Presenter:
Eoin Mckinney, MD (Virtual) 
and Dirk Homann, MD
University of Cambridge & Mount Sinai
View Dirk Homann’s Biography


4:45 PM - 5:15 PM: Discussion Session: Hot Topics in Autoimmunity

Led by: Simi Ahmed, PhD and Eddie James, PhD

Location: Atlantica Ballroom

5:15 PM - 6:00 PM: FREE TIME/NETWORKING

6:00 PM - 8:00 PM: Poster Session (heavy hors d'oeuvres provided)

Sponsored by Provention

Location: Pristina, Verandina, and Solaria

In-person attendance only

8:00 PM: DINNER (on your own)

02/02/2022

7:00 AM - 8:45 AM: Breakfast & Checkout

Hotel checkout is 12 PM.

If checking out today, please bring luggage to the registration table for the remainder of the meeting.
Note: Breakfast will only be served from 7:00 AM – 8:00 AM.

8:45 AM - 10:15 AM: Cutting Edge Seminar V: Emerging Technologies

Co-Chairs: Amelia Linnemann, PhD and Holger Russ, PhD

Location: Atlantica Ballroom


Update from the Beta Cell Consortium (8:45 AM – 9:15 AM)

Presenter:
Kate White, PhD

University of Southern California
View Biography


Islet function: A splice of life (9:15 AM – 9:45 AM)

Presenter:
Lori Sussell, PhD
University of Colorado


Islet on a chip (9:45 AM -10:15 AM)

Presenter:
Ashu Agarwal, PhD

University of Miami
View Biography


10:15 AM - 10:45 AM: Discussion Session V: Emerging Technologies

Led by: Amelia Linnemann, PhD and Holger Russ, PhD

Location: Atlantica Ballroom

10:45 AM - 11:15 AM: BREAK

11:15 AM - 12:00 PM: Open-mic discussion session: What did we miss and where should we go?

Led by: Alberto Pugliese, MD and Carmella Evans-Molina MD, PhD, and Mark Atkinson PhD