Location: Serenoa

Hotel check-in will be at 4:00 pm. 

Opening Remarks By:

Mark Atkinson, PhD
nPOD Executive Director
The University of Florida
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Carmella Evans-Molina, MD, PhD
nPOD Co-Executive Director
Indiana University
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Alberto Pugliese, MD
nPOD Co-Executive Director
University of Miami
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Location: Atlantica Ballroom

Co-Chairs: Emily Sims, MD and Ivan Gerling, PhD

Location: Atlantica Ballroom

Beta cell mitophagy and mitochondrial dysfunction in T1D (12:15 PM – 12:45 PM) 

Presenter:
Scott Soleimanpour, MD
University of Michigan Medicine
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Cellular Age Mosaicism (12:45 PM – 1:15 PM) – Virtual Presentation

Presenter:
Rafael Arrojo e Drigo, PhD
Vanderbilt University

Beta cell stress responses and senescence in T1D (1:15 PM – 1:45 PM) – Virtual Presentation

Presenter:
Peter Thompson, PhD
University of Manitoba
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Led by: Emily Sims, MD and Ivan Gerling, PhD

Location: Atlantica Ballroom

Co-Chairs: Scott Solimanpour, MD and Joanna Almaça, PhD

Location: Atlantica Ballrooom

Targeting glutamate receptors in human alpha cells restores glucagon secretion in type 1 diabetes (2:45 PM – 3:00 PM)

Presenter:
Julia Panzer, PhD
University of Miami
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12-Lipoxygenase Activates the integrated stress Presponse in Pancreatic Islets, Supresses PD-L1 Production, and promotes the development of T1D (3:00 PM – 3:15 PM) – Virtual Presentation

Presenter:
Abhishek Kulkarni, PhD
University of Chicago
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Lessons on human beta cell biology from comprehensive methylome analysis (3:15 PM – 3:30 PM) – Virtual Presentation

Presenter:
Yuval Dor, PhD
The Hebrew University of Jerusalem
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Elevated islet prohormone ratios as indicators of insulin dependency in islet transplant recipients (3:30 PM – 3:45 PM) – Virtual Presentation

Presenter:
Yi-Chun Chen, PhD
University of British Columbia
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Regulation of glucose metabolism by posttranslational modifications in Type 1 Diabetes (3:45 PM – 4:00 PM) – Virtual Presentation

Presenter:
Mark Mamula, PhD
Yale University School of Medicine
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Co-Chairs: Alberto Pugliese, MD and Dirk Homann MD, PhD

Location: Atlantica Ballroom

Modeling EV infection in pancreas slices (4:00 PM – 4:20 PM)

Presenter:
Mehdi Benkhala, PhD
La Jolla Institute for Immunology
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Gene expression and antiviral response profiles distinguish children who develop insulin or GAD-driven autoimmunity – the TEDDY study (4:20 PM – 4:40 PM)

Presenter:
Matti Nykter, PhD
Tampere University
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Enterovirus Vaccination Trial and Teplizumab update (4:40 PM – 4:55 PM) – Virtual Presentation

Presenter:
Francisco Leon, MD, PhD
Provention
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Co-Chairs: Alberto Pugliese, MD and Dirk Homann, MD, PhD

Location: Atlantica Ballroom

Location: Pristina and Verandina

Presenter:
Maki Nakayama, MD, PhD
University of Colorado School of Medicine
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Location: Atlantica Ballroom

Location: Serenoa

Hotel check-in will begin at 4:00 pm.

Location: Pristina and Verandina

Co-Chairs: Todd Brusko, PhD and Mark Rigby, MD, PhD

Location: Atlantica Ballroom

Altered frequencies of TEMRA and CXCR3-positive cells among autoreactive CD4 T cells associated with recurrent islet autoimmunity in recipients of simultaneous pancreas-kidney transplants (8:00 AM – 8:15 AM)

Presenter:
Alberto Pugliese, MD
University of Miami
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Activation and trafficking of insulin-binding B cells to the pLN in nPOD donors (8:15 AM – 8:30 AM)

Presenter:
Mia Smith, PhD, DVM
Barbara Davis Center for Diabetes
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Recognition of a splice variant neo-epitope by CD4+ T cells in subjects with Type 1 Diabetes (8:30 AM – 8:45 AM)

Presenter:
Eddie James, PhD
Benaroya Research Institute
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Co-Chairs: Jamie Felton, MD and Thomas Delong, PhD
Location: Atlantica Ballroom

Human tissue-resident memory T cells/pancreas (8:45 AM – 9:15 AM)

Presenter:
Donna Farber, PhD
Columbia University
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Emerging concepts around CD8 Biology (9:15 AM – 9:45 AM) – Virtual Presentation

Presenter:
Marcus Buggert, PhD
Karolinska Institute
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Development of adaptive immune responses in central and peripheral lymphoid tissues  (9:45 AM – 10:15 AM) – Virtual Presentation

Presenter:
Maigan Brusko, PhD
University of Florida

Discovery of novel autoantigens (10:15 AM – 10:45 AM) – Virtual Presentation

Presenter:
Roberto Mallone, MD, PhD
Institut National de la Santé et de la Recherche Médicale
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Led by: Jamie Felton, MD and Thomas Delong, PhD

Location: Atlantica Ballroom

New paradigms for islet genetics and transplantation tolerance: implications for diabetes research

Presenter: 
Seung Kim, MD, PhD
Stanford University
Virtual Presentation

Location: Atlantica Ballroom

Location: Pristina and Verandina

Co-Chairs: Teresa Mastracci, PhD and Carmella Evans-Molina, MD, PhD

Location: Atlantica Ballroom

Pancreas imaging in T1D (1:30 PM – 2:00 PM)

Presenter:
Jack Virostko, PhD
Dell Medical School
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Exocrine pancreatic infiltrates (2:00 PM – 2:30 PM)

Presenter:
Kyle Gaulton, PhD
University of California San Diego
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Pancreas Vagal Neuroanatomy (2:30 PM – 3:00 PM) – Virtual Presentation

Presenter:
Martha Campbell-Thompson, DVM, PhD
University of Florida
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Led by: Teresa Mastracci, PhD and Carmella Evans-Molina, MD, PhD

Location: Atlantica Ballroom

Co-Chairs: Jason Spaeth, PhD and Alice Long, PhD

Location: Atlantica Ballroom

Pre-clinical Evaluation of TYK2 Inhibitors as a Therapy for Type 1 Diabetes (3:45 PM – 4:00 PM) – Virtual Presentation

Presenter:
Farooq Syed, PhD
Indiana University School of Medicine
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β-cell targeting of immune suppressive agonists in human pancreas tissue slices (4:00 PM – 4:15 PM)

Presenter:
Matthew Becker, PhD(c)
University of Florida
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β-cell targeted Immune Suppressive PD-1 Bispecific Agonists – a Novel Approach to Treat Type 1 Diabetes (4:15 PM – 4:30 PM) – Virtual Presentation

Presenter:
Giovanni Bossi, PhD
Immunocore ltd
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View Abstract

View virtual posters and videos here.

Link: https://tinyurl.com/2bdvcvv9 
Meeting ID: 824 5897 3710 
Password: 941422 

Location: Verandina

Location: Pristina and Verandina

Co-Chairs: Klaus Kaestner, PhD and Clayton Mathews, PhD

Location: Atlantica Ballroom

ZT-01, a First-in-class SSTR2 Antagonist to Prevent Hypoglycemia in Insulin Dependent Diabetes (8:00 AM – 8:30 AM)

Presenter:
Richard Liggins, PhD
Zucara Therapeutics

Targeting GIP/GLP-2 Receptors to Prevent Hypoglycemia in Type 1 Diabetes (8:30 AM – 9:00 AM) – Virtual Presentation

Presenter:
Filip Knop, MD, PhD
Gentofte Hospital, University of Copenhagen

Alpha Cell Dysfunction Precedes Beta Cell Loss in T1D (9:00 AM – 9:30 AM)

Presenter:
Doris Stoffers, MD, PhD
University of Pennsylvania

Led by: Klaus Kaestner, PhD and Clayton Mathews, PhD

Location: Atlantica Ballroom

Co-Chairs: Alberto Pugliese, MD and Edward Phelps, PhD

Location: Atlantica Ballroom

Changes in the human microvasculature during T1D (10:30 AM – 10:50 AM)

Presenter:
Joana Almaça, PhD
University of Miami Miller School of Medicine
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Characterizing endocrine cell ross talk in human islets in situ during T1D progression (10:50 AM – 11:10 AM)

Presenter:
Richard Benninger, PhD
University of Colorado Denver
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The importance of stress pathways in Diabetes (11:10 AM – 11:30 AM) – Virtual Presentation

Presenter:
Feroz Papa, MD, PhD
University of California San Francisco
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Chair: Lori Sussel, PhD and Esther Latres, PhD

Location: Atlantica Ballroom

Type 2 diabetes-associated TCF7L2 genetic variants and African American race protect from loss of insulin containing islets in type 1 diabetes (11:30 AM – 11:45 AM)

Presenter:
Maria Redondo, MD, PhD
Baylor College of Medicine, Texas Children’s Hospital
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View Abstract

Single nucleus-resolved chromatin accessibility profiles of pancreatic islet cells (11:45 PM – 12:00 PM)

Presenter:
Michelle Lee
University of Pennsylvania
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Humoral Factors and Circulating Extracellular Vesicles in Type 1 Diabtes Induce Beta Cell Cytoxicity (12:00 AM – 12:15 PM) – Virtual Presentation

Presenter:
Nagesha Guthal Kondegowda, PhD
Arthur Riggs Diabetes and Metabolism Institute, City of Hope National Medical Center
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Location: Pristina and Verandina

Sharks: Desmond Schatz, MD, Chantal Mathieu, MD (Virtual), Jessica Dunne, PhD, and Bart Roep, PhD (Virtual)

Location: Atlantica Ballroom 

What do single autoantibody positive tell us in terms of disease prediction? (1:30 PM – 1:50 PM) – Virtual Presentation

Presenter:
Ezio Bonifactio, PhD
Technische Universität Dresden

What do metabolic data from clinical cohorts tell us? (1:50 PM – 2:10 PM)

Presenter:
Maria Redondo, MD, PhD
Baylor College of Medicine, Texas Children’s Hospital
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Is autoantibody positivity important for islet MHC expression? (2:10 PM – 2:30 PM)

Presenter:
Estefania Quesada-Masachs, MD, PhD
La Jolla Institute for Immunology
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Dealing with false positives and overlap forms of diabetes (2:30 PM – 2:50 PM) – Virtual Presentation

Presenter:
Angus Jones, PhD
University of Exeter College of Medicine and Health
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Are there unique features in single autoantibody positive pancreas? (2:50 PM – 3:10 PM)

Presenter:
Mark Atkinson, PhD
University of Florida

Open Discussion (3:10 PM – 3:30 PM)

Co-Chairs: Simi Ahmed, PhD and Eddie James, PhD

Responder and nonresponder analysis in T1D prevention trials (3:45 PM – 4:15 PM)

Presenter:
Alice Long, PhD
Benaroya Research Institute
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Immune signatures in T1D (4:15 PM – 4:45 PM)

Presenter:
Eoin Mckinney, MD (Virtual) and Dirk Homann, MD
University of Cambridge & Mount Sinai
View Dirk Homann’s Biography

Led by: Simi Ahmed, PhD and Eddie James, PhD

Location: Atlantica Ballroom

Sponsored by Provention

Location: Pristina, Verandina, and Solaria

In-person attendance only

Hotel checkout is 12 PM.

If checking out today, please bring luggage to the registration table for the remainder of the meeting.
Note: Breakfast will only be served from 7:00 AM – 8:00 AM.

Co-Chairs: Amelia Linnemann, PhD and Holger Russ, PhD

Location: Atlantica Ballroom

Update from the Beta Cell Consortium (8:45 AM – 9:15 AM)

Presenter:
Kate White, PhD
University of Southern California
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Islet function: A splice of life (9:15 AM – 9:45 AM)

Presenter:
Lori Sussell, PhD
University of Colorado

Islet on a chip (9:45 AM -10:15 AM)

Presenter:
Ashu Agarwal, PhD
University of Miami
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Led by: Amelia Linnemann, PhD and Holger Russ, PhD

Location: Atlantica Ballroom

Led by: Alberto Pugliese, MD and Carmella Evans-Molina MD, PhD, and Mark Atkinson PhD