Meeting Agenda – PDF View
02/19/2024
10:00 AM - 5:30 PM: Registration
Location: Lobby
12:00PM - 1:30PM: Lunch
Location: Miramar
1:30 PM - 1:35 PM: Opening Remarks
Location: Lagunita Pavilion
Alberto Pugliese, MD, Carmella Evans-Molina, MD PhD and Mark Atkinson, PhD
nPOD Executive Directors
1:35 PM - 1:45 PM: Perspectives from a PWD and Part-Time Caregiver
Location: Lagunita Pavilion
Kyle J. Rose, MBA
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Introduction by Esther Latres, PhD
1:45 PM - 3:00 PM: Cutting Edge Seminar I: Differences in T1D Between Children and Adults
Location: Lagunita Pavilion
Co-Chairs: Sarah Richardson, PhD and Todd Brusko, PhD
Characteristics of T1D in Children and Adults (1:45 PM – 2:10 PM)
Presenter: Kathleen Gillespie, PhD
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Age and Genetic Correlates with Type 1 Diabetes (2:10 PM – 2:35 PM)
Presenter: Nicholas Thomas, MD PhD
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Considering Age in Immune Correlates of Response (2:35 PM – 3:00 PM)
Presenter: Alice Long, PhD
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3:00 PM - 3:45 PM: Discussion Session I: Differences in T1D Between Children and Adults
Location: Lagunita Pavilion
Led by: Sarah Richardson, PhD and Todd Brusko, PhD
3:45 PM - 4:15 PM: Break
4:15 PM - 5:30 PM: Cutting Edge Seminar II: Prohormone or Post Translational Antigenic Processing Defects in the T1D Pancreas
Location: Lagunita Pavilion
Co-Chairs: Teresa Rodriguez-Calvo, PhD and Emily Sims, MD
Proinsulin: Sometimes Things Go Wrong (4:15 PM – 4:40 PM)
Presenter: Peter Arvan, MD PhD
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DNA Methylation-Based Assessment of Cell Composition in Human Pancreas and Islets (4:40 PM – 5:05 PM)
Presenter: Zeina Drawshy, MS
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Insulin Neoepitopes Induced by Oxidative Posttranslational Modifications in Type 1 Diabetes (5:05 PM – 5:30 PM)
Presenter: Rocky Strollo, MD PhD
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5:30 PM - 6:15 PM: Discussion Session II: Prohormone or Post Translational Antigenic Processing Defects in the T1D Pancreas
Location: Lagunita Pavilion
Led by: Teresa Rodriguez-Calvo, PhD and Emily Sims, MD
6:15PM - 6:30PM: Break
6:30 PM - 7:15 PM: George Eisenbarth Memorial Lecture
Interdicting Type 1 Diabetes – A 40 Year Perspective
Location: Lagunita Pavilion
Presenter: Jay Skyler, MD
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7:15 PM - 8:15 PM: Reception
Location: Miramar
Light hors d’oeuvres provided
8:15 PM: Dinner (on your own)
02/20/2024
7:30 AM - 4:30 PM: Registration
Location: Lobby
7:00 AM - 8:30 AM: Breakfast
Location: Miaramar
7:30 AM - 8:30 AM: Special Breakfast Meeting: The Downsides of Academic Excellence: The Environmental Impact of the Academic Enterprise and Who is Responsible for Eliminating It?
Location: Luna Solstice
Led by: Mark Huising, PhD
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Submit questions here!
8:30 AM - 9:15 AM: Keynote Speaker
Atoms Up – Targets to Treatments
Location: Lagunita Pavilion
Presenter: John Williams, PhD
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9:15 AM - 10:30 AM: Cutting Edge Seminar III: The Role of the Exocrine Pancreas in T1D Development
Location: Lagunita Pavilion
Co-Chairs: Martha Campbell-Thompson, PhD and Teresa Mastracci, PhD
Genomic Changes in the Exocrine Pancreas in T1D At-Risk Individuals (9:15 AM – 9:40 AM)
Presenter: Kyle Gaulton, PhD
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Exocrine Pancreas Development: Any Alterations in T1D? (9:40 AM – 10:05 AM)
Presenter: Jordan Wright, MD PhD
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In Situ Assessment of Exocrine Cell Function in Health and Disease (10:05 AM – 10:30 AM)
Presenter: Stephan Speier, PhD
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10:30 AM - 11:15 AM: Discussion Session III: The Role of the Exocrine Pancreas in T1D Development
Location: Lagunita Pavilion
Led by: Martha Campbell-Thompson, PhD and Teresa Mastracci, PhD
11:15 AM - 11:45 AM: Break
11:45 AM - 12:25 PM: Oral Abstracts I: Clinical Studies
Location: Lagunita Pavilion
Co-Chairs: Esther Latres, PhD and Josh Vieth, PhD
Single Cell Profile of Islet-Specific Responses in Type 1 Diabetes (11:45 AM – 11:55 AM)
Presenter: Tim Tree, PhD
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Human Leukocyte Antigen Risk Loci for Type 1 Diabetes Associate with T Cell Receptor Motif in Peripheral Blood and Pancreatic Lymph Nodes (11:55 AM – 12:05 PM)
Presenter: Melanie Shapiro, PhD
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Targeting the Glucose Transporter GLUT1 to Control T Cell Activation (12:05 PM – 12:15 PM)
Presenter: Carla Di Dedda, PhD
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Circulating miR-150-5p, a B-lymphocyte Associated miRNA, is Increased Selectively in Plasma of Young Children (<7y) with Recent Onset Type 1 Diabetes (12:15 PM – 12:25 PM)
Presenter: Guido Sebastiani, PhD
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12:25 PM - 1:15 PM: Lunch
Location: Miramar
1:15 PM - 2:55 PM: Cutting Edge Seminar IV: In Vivo and In Vitro Translational Studies to Advance Therapies for T1D
Location: Lagunita Pavilion
Co-Chairs: Juan Dominguez-Bendala, PhD and Alberto Pugliese, MD
Pancreas Slice Live Tissue Platforms Overview, Pros and Cons, Ongoing & Potential Applications I (1:15 PM – 1:40 PM)
Presenter: Julia Panzer, PhD
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Ongoing & Potential Applications II (1:40 PM – 2:05 PM)
Presenter: Ed Phelps, PhD
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Artificial Organ Platforms for T1D (2:05 PM – 2:30 PM)
Presenter: Juan Alvarez, PhD
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Advanced Humanized Mice Platforms for Modeling T1D and Response to Therapy (2:30 PM – 2:55 PM)
Presenter: Audrey Parent, PhD
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2:55 PM - 3:40 PM: Discussion Session IV: In Vivo and In Vitro Translational Studies to Advance Therapies for T1D
Location: Lagunita Pavilion
Led by: Juan Dominguez-Bendala, PhD and Alberto Pugliese, MD
3:40 PM - 4:00 PM: Break
4:00 PM - 4:50 PM: Oral Abstracts II: Novel Concepts for Therapeutics
Location: Lagunita Pavilion
Co-Chairs: Maryaline Coffre, PhD and Erica Cai, PhD
Development of a Beta-Cell Targeted Immune Modulating PD-1 Bispecific Agonist to Suppress Immune Cells and Treat Type 1 Diabetes (4:00 PM – 4:10 PM)
Presenter: Giovanni Bossi, PhD
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Targeting of the Lysine Deacetylase, HDAC6, in Pancreatic Beta-Cells as a Potential Means to Slow the Progression of Type 1 Diabetes (4:10 PM – 4:20 PM)
Presenter: Noel Morgan, PhD
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Combinatorial Genetic Engineering Strategy for Antigen Specific Immune Protection of Stem Cell-Derived Beta Cells (4:20 PM – 4:30 PM)
Presenter: Jessie Barra, PhD
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Unveiling Novel T-Cell Receptors (TCRs) for Enhanced Treg Cell Therapy in Type 1 Diabetes (T1D) (4:30 PM – 4:40 PM)
Presenter: Geetha Mylvaganam, PhD
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Upregulation of PDL-1 on Endogenous Pancreatic Islet β Cells by saRNA-Aptamer Chimera (4:40 PM – 4:50 PM)
Presenter: Victoria Kuznetsova
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4:50 PM - 5:20 PM: Questions Asked and Lessons Learned from HIRN HPAP T1D
Location: Lagunita Pavilion
Led by: Klaus Kaestner, PhD
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5:20 PM - 7:00 PM: Free Time/Networking (Includes Annual Meeting Photo)
Includes annual meeting photos during California sunset
Sunset predicted at 5:41 PM – please meet at 5:30 PM
Organized by: Alberto Pugliese, MD
7:00 PM - 10:00 PM: Dinner, Awards Ceremony & nPOD Has Talent
Location: Salon de Reyes Ballroom
02/21/2024
7:00 AM - 8:30 AM: Breakfast
Location: Salon de Reyes Ballroom
7:30 AM - 8:30 AM: Special Breakfast Meeting: Overcoming Barriers to Leadership Development
Location: Luna Solstice
Led by: Jessica Dunne, PhD, Georgia Fousteri, PhD Amelia Linnemann, PhD, Raghu Mirmira, MD PhD and Hubert Tse, PhD
Submit questions for the panel here!
8:30 AM - 10:10 AM: Cutting Edge Seminar V: β- and Islet-Cell Specific Targets
Location: Lagunita Pavilion
Co-Chairs: Roberto Mallone, MD PhD and Qizhi Tang, PhD
Many Antigen Targets, Which Ones Matter? (8:30 AM – 8:55 AM)
Presenter: Roberto Mallone, MD PhD
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Antigen Specific Cell Therapies (8:55 AM – 9:20 AM)
Presenter: Qizhi Tang, PhD
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Autoantigens and Neoantigens: Current Status and Relevance to Prediction and Prevention (9:20 AM – 9:45 AM)
Presenter: Aaron Michels, MD
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It’s up in the AIRR – the Adaptive Immune T Cell Receptor Repertoire in T1D (9:45 AM – 10:10 AM)
Presenter: Todd Brusko, PhD
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10:10 AM - 10:55 AM: Discussion Session V: β- and Islet-Cell Specific Targets
Location: Lagunita Pavilion
Led by: Roberto Mallone, MD PhD and Qizhi Tang, PhD
10:55 AM - 11:25 AM: Break
11:25 AM - 12:55 PM: Shark Tank III
When Does Type 1 Diabetes Actually Begin and Do We Need a Modification to the Current Staging Model?
Location: Lagunita Pavilion
Sharks: Emily Sims, MD, Al Powers, MD and David Leslie, MD
Piranha: Laura Jacobsen, MD (11:25 AM – 11:40 AM)
Piranha: Jessica Dunne, PhD (11:40 AM – 11:55 AM)
Piranha: David Harlan, MD (11:55 AM – 12:10 PM)
Piranha: Alberto Pugliese, MD (12:10 PM – 12:25 PM)
Audience Response (12:25 PM – 12:55 PM)
12:55 PM - 2:00 PM: Lunch
Location: Vista del Mar
2:00 PM - 2:30 PM: Hot Topic: Progress in Understanding Functional Beta and Alpha Cell Heterogeneity
Location: Lagunita Pavilion
Led by: Mark Huising, PhD
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2:30 PM - 3:45 PM: Cutting Edge Seminar VI: How Can nPOD Studies Better Guide Clinical Trials Seeking to Understand Disease and Racial Diversity?
Location: Lagunita Pavilion
Co-Chairs: Maria Redondo, MD, PhD, MPH and Richard Oram, PhD
Diversity and Equity in T1D Clinical Trials (2:30 PM – 2:55 PM)
Presenter: Susanne Cabrera, MD
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T1D and T2D in Diverse Pediatric Populations: Lessons From the DISCOVER Study (2:55 PM – 3:20 PM)
Presenter: Maria Redondo MD, PhD, MPH
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T1D Racial Diversity: Lessons From the TEDDY Study (3:20 PM – 3:45 PM)
Presenter: Kendra Vehik, PhD, MPH
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3:45 PM - 4:30 PM: Discussion Session VI: How Can nPOD Studies Better Guide Clinical Trials Seeking to Understand Disease and Racial Diversity?
Location: Lagunita Pavilion
Led by: Maria Redondo, MD, PhD, MPH and Richard Oram, PhD
4:30 PM - 6:00 PM: Break
6:00 PM - 8:00 PM: Poster Session
Location: Salon de Reyes Ballroom
Hors d’oeuvres provided
8:00 PM: Dinner (on your own)
02/22/2024
7:00 AM - 8:30 AM: Breakfast & Checkout
Hotel checkout is 11 AM.
If checking out today, please bring luggage to the back of the meeting room for the remainder of the meeting.
Location: TBD due to weather
8:30 AM - 9:20 AM: Oral Abstracts III: Pathogenic Mechanisms
Location: Lagunita Pavilion
Co-Chairs: Oliver Blondel, MD and Mark Mamula, PhD
Islet Expression of Classical and Non-Classical HLA-I in Type 1 Diabetes – Signs of a Struggle? (8:30 AM – 8:40 AM)
Presenter: Christina Lekka
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Extracellular Vesicle PD-L1: From Cellular Dynamics to Clinical Implications in Type 1 Diabetes (8:40 AM – 8:50 AM)
Presenter: Chaitra Rao, PhD
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Spatial Transcriptomic Profiling and Cell Type Identification of Human Donor Paired Pancreas and Pancreatic Lymph Nodes Reveals Shared and Unique Tissue Specific Immune Responses at Distinct Stages of T1D (8:50 AM – 9:00 AM)
Presenter: Miguel Medina-Serpas
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Cycling Alpha Cells in Human Pancreatic Islets as a Potential Key Reservoir for Beta Cell Loss (9:00 AM – 9:10 AM)
Presenter: Esra Karakose, PhD
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Modeling Heterogenous Islet Inflammation (9:10 AM – 9:20 AM)
Presenter: Yuval Dor, PhD
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9:20 AM - 10:00 AM: Break/Check Out
10:00 AM - 10:30 AM: AI in Type 1 Diabetes
Location: Lagunita Pavilion
Presenter: Vibha Anand, PhD
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10:30 AM - 11:00 AM: What Questions Were Not Asked That Should Have Been Asked?
Location: Lagunita Pavilion
Co-Chairs: Mark Atkinson, PhD, Alberto Pugliese, MD and Carmella Evans-Molina, MD PhD
11:00 AM - 11:15 AM: End of Meeting Remarks
Location: Lagunita Pavilion
Alberto Pugliese, MD, Carmella Evans-Molina, MD PhD and Mark Atkinson, PhD
nPOD Executive Directors