nPOD. Current nPOD Projects
- Use of T1D pancreastic and lymphoid tissue to assess the expression of adhesion molecules
- Investigating islet alpha-to-beta cell conversion in Diabetes
- Analysis of Immunocytes in Human Islets of Type 1 Diabetes Patients
- Mechanisms and dynamics of GAD and GABA in human beta cells
- Characterization of Mesencymal Stem Cells in T1D
- Phenotype, specificity, diversity and clonal spread of B cells in T1DM
- Diabetes and Pancreatic Cancers: Pilot study with molecular profiling
- Beta-cell destruction and preservation in early and late onset type 1 diabetes
- Characterization of new cell markers associated with beta cell failure in diabetes
- Novel recombinant antibodies directed to diabetes-associated autoreactive T cell epitopes
- In Site TO-Seq Profiling of Gene Expression and Proteins in T2D
- Molecular mechanisms of iron uptake by pancreatic beta cells and their contribution to the development of diabetes
- Ljungan virus in T1D
- Tracking islet autoantigen specific CD4+ T Cells
- De-differentiation during progression of beta cell loss in type 1 diabetes
- Disruption of tolerance by ER-stress in type 1 diabetes
- Linking IHC immune profiles of duodenum and pancreas in T1D
- Insulin interacting proteins and stress markers in T1D
- Molecular signatures of islet inflammation in type 1 diabetes
- Beta-cell Death and Survival
- Beta-cell stress signatures and infection in T1D islets
- In situ gene profiling and identification of T1D disease mechanisms
- Identifying and Validating Noncoding RNAs as Human Beta Cell-Specific Biomarkers
- To identify mRNA and miRNA biomarkers associated with exosomes that predict the onset of T1D
- Pancreatic GLP-1 vs glucagon production in healthy and diabetic patients
- The patterns of NADPH oxidase-1 expression in the course of human diabetes
- ARC, a novel beta cell survival factor in type 2 diabetes
- Targeting AID expressing B-lymphocytes as possible clinically applicable T1D intervention
- ORIGINAL: Beta cell regeneration for Type 1 Diabetes ADDENDUM: Neuro-insular pathways regulating beta cell regeneration
- Investigate the molecular link between increased risk of diabetes among patients with psychiatric disorders
- Genetics of nPOD
- T follicular helper (TFH) and regulatory (TFR) cells in T1D
- Imaging pancreatic beta-cells with PET neuroimaging agents
- Epigenetic regulation of beta-cell function and identity
- The immunogenicity of abnormal catabolites of insulin metabolism
- Fibroblast Activation Protein in Type 1 Diabetes
- Evaluation of HERV-W Envelope antigen expression in Pancreas and serum from patients with Type 1 Diabetes.
- The nPOD-Virus Group
- Role of influenza viruses in the etiopathogenesis of diabetes
- Virome and microbiome in T1D onset
- Virus detection in pancreas and other tissues
- Viral sequence discovery by high throughput DNA sequencing of the nPOD diabetic pancreatic samples
- Persistent organic pollutants in the pancreatic tissue of people with and without diabetes
- Enteroviral infection as a causative factor in type 1 diabetes
- Enteroviral infection and T1D
- Different expression of extracellular CAR in islets in pancreatic sections and isolated islets
- Detection of enteroviruses in lymphoid tissue of donors with T1D of short duration and attempts to identify the infected cell type(s)
- Mapping the histopathological landscape of human T1D: a pilot study (CLARITY)
- IL-1beta expression in cystic fibrosis diabetes
- Joslin Medalist Study
- Nanotomy of human islets of Langerhans in type 1 diabetes
- Peri-capsular basement membrane degradation during leukocyte penetration Into the pancreatic islet during development of human type 1 diabetes and tertiary lymphoid organs in human T1D
- Pathological changes associated with chronic RelB activation in T1D
- Pancreatic duct glands in type 1 diabetes
- Histological differences between Japanese and Western type 1 diabetes
- Extracellular matrix involvement in type 1 diabetes pancreatic islet destruction
- Do de-granulated ß-cells persist in type 1 diabetes?
- Characterization of type 1 diabetes subsets
- “Empty Beta Cells” in type 1 diabetes
- Urocortin 3 as a sensitive marker for beta cell function
- IL-21/IL-21R and GLP-1R staining on pancreas tissues from (pre-)T1D, T2D and control donors
- Human pancreatic tissue proteome of type 1 diabetes
- Protein based biomarkers for type 1 diabetes
- In vivo imaging of islets
- Determination of specific and non-specific binding of 18F-FP-DTBZ in whole pancreas homogenates obtained from controls and patients with longstanding type 1 diabetes
- Comparison of total pancreatic insulin content and peripheral markers of beta cell function and desctruction
- Assessment of memory T cells in the insulitis lesion
- Redox regulation of anti-viral responses in type 1 diabetes
- Molecular insights into the type 1 diabetes pancreas
- Identification of islet associated immune cells in type 2 diabetic patients and further exploration of their role in disease progression and severity
- Tracking the loss of anergic B cells in pre-diabetic and new onset T1DHLA Testing
- Analysis and comparison of IL-18, IL-18R, CCL19 and CCL21 expression in T1D, T2D, autoantibody positive and control samples
- Analysis of the antigen-specific T cell repertoire in T1D patients
- Maternal microchimerism in T1D pancreas
- Vascular endothelial growth factor receptor signaling regulates the pathogenesis of type 1 diabetes
- Tracing effector and regulatory T cell populations in type 1 diabetes
- Tissue-selective chemokines and adhesion molecules in human T1D
- The role of IL-15 and IL-15Ra in the pathogenesis of type 1 diabetes
- In situ detection of pro-inflammatory cytokines within pancreatic islets from diabetic subjects
- TCR signal transduction in diabetogenic T cells
- Role of mucosal epithelium in autoreactivity
- Risk of autoimmune disease and human self-antigen expression
- Reconstitution of HHLS mice with bone marrow from patients with T1DM
- Pancreatic expression of chemokines in human type 1 diabetes
- Molecular Signature of Autoimmune T cells in Type 1 Diabetes and Treg TCR deep sequencing. Detect Cd226+ Treg and Teff ininsulitis patient samples
- Microarray analysis of PLN from autoantibody positive donors
- Dynamic Survey of T Cell Repertoire Targeting Pancreatic Beta Cells
- Investigation of B cells in human islets and PLN in T1
- Identification of T1D-specific Fab fragments of IA-2 dominant conformational epitope
- Identification of novel Tissue-Specific Antigens expressed by human Extrathymic Aire-Expressing Cells, and determination of their potential contribution to the prevention of type 1 diabetes
- Humoral immunity in type 1 diabetes
- Fas Ligand: Unorthodox target for prevention of type 1 diabetes
- Dissecting the effector/regulatory compartments in the target tissues of T1D
- Diabetogenic function of autoimmune donor splenocytes in humanized mice
- Detection of islet autoreactive CD8 T-cells in insulitis versus periphery
- Correlation of Islet Autoantigen-Specific T-Cell Repertoire in the Pancreatic Lymph Nodes and Peripheral Blood in T1D Autoimmunity
- Characterization of autoantigen-specific T cell receptors from PLNs
- Denver AAb Core
- Northwest Lipid Research
- UF AAb Core
- MODY mutation testing
- High resolution HLA typing
- Pancreatic immunologic and metabolic parameters
- Immunochip Assays
- Microangiopathy in diabetic bone marrow
- Intrinsic immunoregulatory defect of bone marrow mesenchymal stem cells (BM-MSC) from T1D patients
- Bone marrow progenitor cell (BMPCs) dysfunction in diabetes is mediated by reduced bioavailability of NO
- Role of Calcium-Independent Phospholipase A2β (iPLA2β) on β-Cell Apoptosis
- Confirmation of target gene expression in T1D and T2D pancreas
- Deoxyhypusine synthase: a novel target for beta cell protection
- Analysis of Islet Enriched Transcription Factor Expression and Activity in Normal & Type 2 Diabetic Islets
- Glucagon secretion and islet neuropathy
- Defining islet heterogeneity using single islet transcriptomics
- Markers of stress in diabetic islets
- Islet resistance to T1D
- Pancreatic islet biology and vascularization
- ORIGINAL: Immunohistochemical identification of molecular markers of oxidative and nitrosative stress in β-cells during the early stages of human type 1 diabetes mellitus ADDENDUM: Beta cell stress as an early preceding phase of autoimmune type 1 diabetes (T1D): Immunohistochemical assessment of markers of early beta cell vulnerability in newly-diagnosed and long-term diabetic cases
- Heparan sulfate levels mark the health status of human islet β-cells
- Examination of ER stress markers in type 1 diabetes samples in humans
- E-cadherin mediates developmental effects on the proliferation and the function of β-cells in the islet of Langerhans
- Characterization of beta cell ER stress associated to enteroviral infection in type 1 diabetes
- Identification of a gene regulating pancreatic beta cell replication
- Beta cell defects in cystic fibrosis related diabetes
- 12/15 Lipoxygenase expression in type 1 diabetes
- Preventing beta cell dedifferentiation in type 1 diabetes
- Beta cell replication
- Cell conversion in the human pancreas
- Progenitors of the beta cell lineage in the pancreas and biliary tree of diabetic patients
- ORIGINAL: Beta-cell regeneration by transdifferentiation ADDENDUM: Assessment of Islet Cell Transdifferentiation in Type 1 Diabetes
- Quantitative and qualitative evaluation of the endocrine & exocrine pancreas in type 1 diabetes
- Multidisciplinary approaches to driving human beta cell replication
- Investigating the de-differentiated state of the β-cell in human diabetic patient tissues
- Generation of tools to distinguish human pancreatic cell populations
- Generation of pluripotent stem cells from diabetics ADDENDUM: Generation of iPS cell lines from a majority of T1D cases
- Beta cell dedifferentiation in type 2 diabetes