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Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Autoreactive T cells specific for beta cell antigens have previously been identified from the peripheral blood of type 1 diabetes (T1D) patients, and immune cells within the pancreatic insulitis lesion been immunophenotyped from human organ donor tissues. However, this report by Babon et al. represents one of the first and most extensive studies of T cell lines grown from handpicked islets from nine organ donors with T1D.
Tissue Distribution and Clonal Diversity of the T and B Cell Repertoire in Type 1 Diabetes
Autoreactive CD4+ and CD8+ T cells have been identified from the peripheral blood and islets of type 1 diabetes (T1D) patients and organ donors, and autoantibodies secreted by autoreactive B cells are the most widely used biomarker of T1D. However, the T1D adaptive immune repertoire had not been examined without preselecting for known cell reactivities.
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