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nPOD Scientific Investigators (updated January 25, 2012)
| Category | Investigator | Institution | Grant Title |
|---|---|---|---|
| Beta Cell Regeneration | Mark Atkinson & Patrick Rowe | University of Florida | The ductal pancreatic progenitor microenvironment in type 1 diabetes |
| Dieter Egli, Ruddy Leibel & Scott Noggle | Columbia University | Generation of pluripotent stem cells from diabetics | |
| Leonard Harrison | The Walter & Eliza Hall Institute of Medical Research | Adult islet progenitor cell markers | |
| Matthias Hebrok | University of California, San Francisco | Investigating the de-differentiated state of the ß-cell in human diabetic patient tissues | |
| Jake Kushner | University of Pennsylvania | Do de-granulated ß-cells persist in type 1 diabetes? | |
| Douglas Melton | Harvard University | Generation of tools to distinguish human pancreatic cell populations | |
| Christopher Rhodes | University of Chicago | "Empty Beta Cells" in type 1 diabetes | |
| Srinath Sanda | Benaroya Research Institute | Analysis of beta cell senescence in T1D subjects | |
| Andrew Stewart & Amy Cox | University of Pittsburgh Medical Center | Multidisciplinary approaches to driving human beta cell replication | |
| Immunology | Mark Stuart Anderson | University of California, San Francisco | Identification of novel Tissue-Specific Antigens expressed by human Extrathymic Aire-Expressing Cells, and determination of their potential contribution to the prevention of type 1 diabetes |
| Manuela Battaglia & Ezio Bonifacio | San Raffaele Scientific Institute | Dissecting the effector/regulatory compartments in the target tissues of T1D | |
| Todd Brusko | University of Florida | Molecular signature of autoimmune T cells in type 1 diabetes | |
| Raphael Clynes | Columbia University | TCR signal transduction in diabetogenic T cells | |
| Howard Davidson | University of Colorado Health Science Center | Characterization of autoantigen-specific T cell receptors from PLNs | |
| Ivana Durinovic-Bello, Thomas Wight and Damien Chaussabel | Benaroya Research Institute | Genetic modification and immunologic checkpoints of proinsulin response | |
| Garry Fathman | Stanford University | Microarray analysis of PLN from autoantibody positive donors | |
| Dale Greiner & Leonard Shultz | University of Massachusetts |
Diabetogenic function of autoimmune donor splenocytes in humanized mice | |
| Abdel Hamad & Thomas Donner | Johns Hopkins University | Fas Ligand: Unorthodox target for prevention of type 1 diabetes | |
| Dolores Jaraquemada, Mercè Martì & Carme Roura-Mir | Universitat Autonoma de Barcelona | Tracing effector and regulatory T cell populations in type 1 diabetes | |
| Sally Kent | University of Massachusetts Medical Center | Investigation of ß cells in human islets and PLN in T1D | |
| Richard David Leslie | University of London | Risk of autoimmune disease and human self-antigen expression | |
| Maki Nakayama & Joe Larkin, III | University of Colorado | Direct replication of T cell receptors specific for type 1 diabetes | |
| Jerry Nepom | Benaroya Research Institute at Virginia Mason | TCR repertoire analysis in type 1 diabetes | |
| Massimo Pietropaolo & Michael Morran | The Brehm Center for Diabetes Research, University of Michigan | Identification of T1D-specific Fab fragments of IA-2 dominant conformational epitope | |
| Alberto Pugliese | Diabetes Research Institute, University of Miami | Beta cells and autoimmunity correlations | |
| Helena Reijonen | Benaroya Research Institute at Virginia Mason | Islet autoantigen specific T cells in progressors and non-progressors | |
| Bart Roep | Leiden University | Detection of islet autoreactive CD8 T-cells in insulitis versus periphery | |
| Suparna Sarkar & Dirk Homann | University of Colorado, Denver | Pancreatic expression of chemokines in human type 1 diabetes | |
| Jo Spencer | King's College London School of Medicine | Phenotype, specificity, diversity and clonal spread of ß-cells in type 1 diabetes | |
| Brad Stone, Bill Kwok & Matthias von Herrath | Benaroya Research Institute | Systematic assessment of autoreactivity in human type 1 diabetes | |
| Matthias von Herrath | University of California, San Diego | In situ detection of pro-inflammatory cytokines within pancreatic islets from diabetic subjects | |
| Thomas Waldmann & Jing Chen | NCI/NIH | The role of IL-15 and IL-15Ra in the pathogenesis of type 1 diabetes | |
| Garth Warnock | University of British Columbia | Characterization of T-cell costimulatory molecules in pancreata from IAPCD | |
| Clive Wasserfall | University of Florida & Indiana University | Humoral immunity in type 1 diabetes | |
| Metabolic and Developmental | Yuval Dor & Benjamin Glaser | Hebrew University of Jerusalem | Markers of stress in diabetic islets |
| Decio Eizirik & Ihsane Marhfour | Univeristè Libre de Bruxelles | Characterization of beta cell ER stress markers in type 1 diabetes | |
| Ivan Gerling | University of Tennessee Health Science Center | Sequencing the islet transcriptome | |
| Maria Grant | University of Florida | Bone marrow progenitor cell (BMPCs) dysfunction in diabetes is mediated by reduced bioavailability of NO | |
| Paul Harris, Masanori Ichise & Matthew Freeby | Columbia University | Determination of specific and non-specific binding of 18F-FP-DTBZ in whole pancreas homogenates obtained from controls and patients with longstanding type 1 diabetes | |
| Kevan Herold & Alfred Bothwell | Yale University | Reconstitution of HHLS mice with bone marrow from patients with T1DM | |
| Gokhan Hotamisligil and Feyza Engin | Harvard University | Examination of ER stress markers in type 1 diabetes samples in humans | |
| Ruddy Leibel & Nao Wakae | Columbia University | E-cadherin mediates developmental effects on the proliferation and the function of ß-cells in the islet of Langerhans | |
| Clayton Mathews | University of Florida | Islet resistance to T1D | |
| Sara Michie & Baohui Xu | Stanford University | Tissue-selective adhesion molecules in human type 1 diabetes | |
| Anna Moore & Amol Kavishwar | Massachusetts General Hospital | In vivo imaging of islets | |
| Jerry Nadler, Margaret Morris & Kaiwen Ma | Eastern Virginia Medical School | 12/15 Lipoxygenase expression in type 1 diabetes | |
| Al Powers | Vanderbilt University | Pancreatic islet biology and vascularization | |
| Shiva Reddy | University of Auckland, New Zealand | Immunohistochemical identification of molecular markers of oxidative and nitrosative stress in ß-cells during the early stages of human type 1 diabetes mellitus | |
| Salvatore Sechi & Akos Vertes | George Washington University | Molecular profile of the pancreatic tissue of long-standing type 1 diabetes patients | |
| Charmaine Simeonovic, Christopher Parish, J. Dennis Wilson & Andrew Ziolowski | Australian National University | Heparan sulfate levels mark the health status of human islet ß-cells | |
| Gerald Taborsky, Jr. | University of Washington | Glucagon secretion and islet neuropathy | |
| Pathology | Vitaly Ablamunits, Kevan Herold & Jasmin Lebastchi | Yale University | Comparison of total pancreatic insulin content and peripheral markers of beta cell funcion and desctruction |
| Jeffrey Bluestone & Armando Villalta | University of California, San Francisco | Vascular endothelial growth factor receptor signaling regulates the pathogenesis of type 1 diabetes | |
| Peter Butler, Alexandra Butler & Mark Atkinson | University of California, Los Angeles | Pancreatic duct glands in type 1 diabetes | |
| Martha Campbell-Thompson & Mark Atkinson | University of Florida | Pancreatic immunologic and metabolic parameters | |
| Roberto Gianani | University of Colorado, Denver | Characterization of type 1 diabetes subsets | |
| Akihisa Imagawa & Toshiaki Hanafusa | Osaka University | Histological differences between Japanese and Western type 1 diabetes | |
| George King & Susan Bonner-Weir | Harvard University | Joslin Medalist Study | |
| Paolo Maddedu & Costanza Emanueli | University of Bristol | Microangiopathy in diabetic bone marrow | |
| Brad Marsh | University of Queensland | 3D structural characterization of human islet dysfunction/destruction | |
Lydia Sorokin & |
University of Muenster | Leukocyte penetration of the peri-capsular basement membrane in human T1D | |
| Scott Swenson | Yale University | Polyploidy in the exocrine pancreas | |
| Ranjeny Thomas & Katharine Irvine | University of Queensland | Pathological changes associated with chronic RelB activation in T1D | |
| Thomas Wight & Susan Perigo | Benaroya Research Institute at Virginia Mason | Extracellular matrix involvement in type 1 diabetes pancreatic islet destruction | |
| Type 1 Diabetes Etiology | Heikki Hyoty | University of Tampere | Detection of enteroviruses in the pancreas and other organs |
| Richard Lloyd & Joseph Petrosino | Baylor College of Medicine | Virome and microbiome in T1D onset | |
| Noel Morgan & Sarah Richardson | Peninsula Medical School | Enteroviral infection as a causative factor in type 1 diabetes | |
| Ake Sjoholm | Karolinska Institute | Ljungan virus in type 1 diabetes patients | |
| John Todd, Vincent Plagnol & Herbert Virgin, IV | University of Cambridge | Characterization of the nPOD samples virome by high throughput DNA sequencing | |
| Antonio Toniolo, Andreina Baj & Roberto Accolla | University of Insubria Medical School | Detection of enteroviruses in lymphoid tissue of donors with T1D of short duration and attempts to identify the infected cell type(s) | |
| Steven Tracy | University of Nebraska | Enterovirus involvement in the etiology of T1D | |
| Eric Triplett & Martha Campbell-Thompson | University of Florida | Gut microbiota in early type 1 diabetes |