nPOD Active Research Projects (91 total as of: May 15, 2013)

Please click here to learn more about each investigator.

Category	Investigator	Institution	Grant Title
Beta Cell Regeneration	Justin Annes	Stanford University	To identify the differential expression of ADK in normal and diabetic individuals
	Mark Atkinson & Patrick Rowe	University of Florida	The ductal pancreatic progenitor microenvironment in type 1 diabetes
	Juan Dominguez-Bendala, Giacomo Lanzoni & Luca Inverardi	University of Miami	Progenitors of the beta cell lineage in the pancreas and biliary tree of diabetic patients
	Dieter Egli, Ruddy Leibel & Scott Noggle	Columbia University	Generation of pluripotent stem cells from diabetics
	Leonard Harrison	The Walter & Eliza Hall Institute of Medical Research	Adult islet progenitor cell markers
	Matthias Hebrok	University of California, San Francisco	Investigating the de-differentiated state of the ß-cell in human diabetic patient tissues
	Pedro Herrera	University of Geneva Medical School	Cell conversion in the human pancreas
	Jake Kushner	Baylor College of Medicine	Do de-granulated ß-cells persist in type 1 diabetes?
	Fred Levine	Sanford-Burnham Medical Research Institute	Beta-cell regeneration by transdifferentiation
	Douglas Melton	Harvard University	Generation of tools to distinguish human pancreatic cell populations
	Christopher Rhodes	University of Chicago	"Empty Beta Cells" in type 1 diabetes
	Srinath Sanda	Benaroya Research Institute	Analysis of beta cell senescence in T1D subjects
	Maike Sander	University of California, San Diego	Preventing beta cell dedifferentiation in type 1 diabetes
	Andrew Stewart & Amy Cox	University of Pittsburgh Medical Center	Multidisciplinary approaches to driving human beta cell replication
Immunology	Reza Abdi & Marwan Mounayar	Brigham and Women's Hospital	Intrinsic immunoregulatory defect of bone marrow mesenchymal stem cells (BM-MSC) from T1D patients
	Mark Stuart Anderson	University of California, San Francisco	Identification of novel Tissue-Specific Antigens expressed by human Extrathymic Aire-Expressing Cells, and determination of their potential contribution to the prevention of type 1 diabetes
	Manuela Battaglia & Ezio Bonifacio	San Raffaele Scientific Institute, Italy	Dissecting the effector/regulatory compartments in the target tissues of T1D
	Todd Brusko	University of Florida	Molecular signature of autoimmune T cells in type 1 diabetes
	Raphael Clynes	Columbia University	TCR signal transduction in diabetogenic T cells
	Howard Davidson	University of Colorado Health Science Center	Characterization of autoantigen-specific T cell receptors from PLNs
	Mark Davis & Ruth Taniguchi	Stanford University	Analysis of the antigen-specific T cell repertoire in T1D patients
	Garry Fathman	Stanford University	Microarray analysis of PLN from autoantibody positive donors
	Dale Greiner & Leonard Shultz	University of Massachusetts	Diabetogenic function of autoimmune donor splenocytes in humanized mice
	Abdel Hamad & Thomas Donner	Johns Hopkins University	Fas Ligand: Unorthodox target for prevention of type 1 diabetes
	Dolores Jaraquemada, Mercè Martì & Carme Roura-Mir	University of Barcelona, Spain	Tracing effector and regulatory T cell populations in type 1 diabetes
	Sally Kent	University of Massachusetts Medical Center	Investigation of ß cells in human islets and PLN in T1D
	Richard David Leslie	University of London	Risk of autoimmune disease and human self-antigen expression
	Maki Nakayama & Joe Larkin, III	University of Colorado	Direct replication of T cell receptors specific for type 1 diabetes
	Lorenzo Piemonti & Ilaria Capua	San Raffaele Scientific Institute, Italy	Role of influenza viruses in the etiopathogenesis of diabetes
	Massimo Pietropaolo & Michael Morran	The Brehm Center for Diabetes Research, University of Michigan	Identification of T1D-specific Fab fragments of IA-2 dominant conformational epitope
	Alberto Pugliese	Diabetes Research Institute, University of Miami	Beta cells and autoimmunity correlations
	Helena Reijonen	Benaroya Research Institute at Virginia Mason	Islet autoantigen specific T cells in progressors and non-progressors
	Bart Roep	Leiden University, Netherlands	Detection of islet autoreactive CD8 T-cells in insulitis versus periphery
	Srinath Sanda & Rebecca Hull	University of California, San Francisco	IL-1beta expression in cystic fibrosis diabetes
	Suparna Sarkar & Dirk Homann	University of Colorado, Denver	Pancreatic expression of chemokines in human type 1 diabetes
	Nora Sarvetnick & Kamiya Mehla	University of Nebraska Medical Center	To identify the role of IL-18R+ CD8 T cell subsets in islet destruction
	Matthias von Herrath	University of California, San Diego	In situ detection of pro-inflammatory cytokines within pancreatic islets from diabetic subjects
	Thomas Waldmann & Jing Chen	NCI/NIH	The role of IL-15 and IL-15Ra in the pathogenesis of type 1 diabetes
	Clive Wasserfall	University of Florida	Humoral immunity in type 1 diabetes
Metabolic and Developmental	David Carpenter, Miquel Porta, Sarah Howard	University of Albany	Persistent organic pollutants in the pancreatic tissue of people with and without diabetes
	Yuval Dor & Benjamin Glaser	Hebrew University of Jerusalem	Markers of stress in diabetic islets
	Decio Eizirik & Ihsane Marhfour	The Free University of Brussels, Belgium	Characterization of beta cell ER stress markers in type 1 diabetes
	Ivan Gerling	University of Tennessee Health Science Center	Sequencing the islet transcriptome
	Kathleen Gillespie	University of Bristol	Maternal microchimerism in T1D pancreas
	Maria Grant	University of Florida	Bone marrow progenitor cell (BMPCs) dysfunction in diabetes is mediated by reduced bioavailability of NO
	Paul Harris, Masanori Ichise & Matthew Freeby	Columbia University	Determination of specific and non-specific binding of 18F-FP-DTBZ in whole pancreas homogenates obtained from controls and patients with longstanding type 1 diabetes
	Kevan Herold & Alfred Bothwell	Yale University	Reconstitution of HHLS mice with bone marrow from patients with T1DM
	Gokhan Hotamisligil & Feyza Engin	Harvard University	Examination of ER stress markers in type 1 diabetes samples in humans
	Ruddy Leibel & Nao Wakae	Columbia University	E-cadherin mediates developmental effects on the proliferation and the function of ß-cells in the islet of Langerhans
	Clayton Mathews	University of Florida	Islet resistance to T1D
	Sara Michie & Baohui Xu	Stanford University	Tissue-selective adhesion molecules in human type 1 diabetes
	Jerry Nadler, Margaret Morris & Kaiwen Ma	Eastern Virginia Medical School	12/15 Lipoxygenase expression in type 1 diabetes
	Al Powers	Vanderbilt University	Pancreatic islet biology and vascularization
	Shiva Reddy	University of Auckland, New Zealand	Immunohistochemical identification of molecular markers of oxidative and nitrosative stress in ß-cells during the early stages of human type 1 diabetes mellitus
	Salvatore Sechi & Akos Vertes	George Washington University	Molecular profile of the pancreatic tissue of long-standing type 1 diabetes patients
	Charmaine Simeonovic, Christopher Parish, J. Dennis Wilson & Andrew Ziolowski	Australian National University	Heparan sulfate levels mark the health status of human islet ß-cells
	Gerald Taborsky, Jr.	University of Washington	Glucagon secretion and islet neuropathy
	Shannon Wallet	University of Florida	Role of mucosal epithelium in autoreactivity
Pathology	Vitaly Ablamunits, Kevan Herold & Jasmin Lebastchi	Yale University	Comparison of total pancreatic insulin content and peripheral markers of beta cell function and desctruction
	Domenico Accili & Chutima Talchai	Columbia University	Beta cell dedifferentiation in type 2 diabetes
	Jeffrey Bluestone & Armando Villalta	University of California, San Francisco	Vascular endothelial growth factor receptor signaling regulates the pathogenesis of type 1 diabetes
	Peter Butler, Alexandra Butler & Mark Atkinson	University of California, Los Angeles	Pancreatic duct glands in type 1 diabetes
	Martha Campbell-Thompson & Mark Atkinson	University of Florida	Pancreatic immunologic and metabolic parameters
	Gun Frisk & Olle Korsgren	Uppsala University, Sweden	Different expression of extracellular CAR in islets in pancreatic sections and isolated islets
	Roberto Gianani	University of Colorado, Denver	Characterization of type 1 diabetes subsets
	Ben Giepmans	University Medical Center Groningen	Nanotomy of human islets of Langerhans in type 1 diabetes
	Akihisa Imagawa & Toshiaki Hanafusa	Osaka University, Japan	Histological differences between Japanese and Western type 1 diabetes
	George King & Susan Bonner-Weir	Harvard University	Joslin Medalist Study
	Paolo Madeddu & Costanza Emanueli	University of Bristol, UK	Microangiopathy in diabetic bone marrow
	Lydia Sorokin & Eva Korpos	University of Muenster, Germany	Leukocyte penetration of the peri-capsular basement membrane in human T1D
	Roland Stein	Vanderbilt University Medical Center	Analysis of Islet Enriched Transcription Factor Expression and Activity in Normal & Type 2 Diabetic Islets
	Ranjeny Thomas & Katharine Irvine	University of Queensland	Pathological changes associated with chronic RelB activation in T1D
	Thomas Wight & Susan Perigo	Benaroya Research Institute at Virginia Mason	Extracellular matrix involvement in type 1 diabetes pancreatic islet destruction
Type 1 Diabetes Etiology	Heikki Hyoty	University of Tampere, Finland	Detection of enteroviruses in the pancreas and other organs
	Richard Lloyd & Joseph Petrosino	Baylor College of Medicine	Virome and microbiome in T1D onset
	Noel Morgan & Sarah Richardson	Peninsula Medical School, UK	Enteroviral infection as a causative factor in type 1 diabetes
	John Todd, Vincent Plagnol & Herbert Virgin, IV	University of Cambridge, UK	Characterization of the nPOD samples virome by high throughput DNA sequencing
	Antonio Toniolo, Andreina Baj & Roberto Accolla	University of Insubria Medical School, Italy	Detection of enteroviruses in lymphoid tissue of donors with T1D of short duration and attempts to identify the infected cell type(s)
	Steven Tracy	University of Nebraska	Enterovirus involvement in the etiology of T1D
	Qibin Zhang and Mark Atkinson	Pacific Northwest National Laboratory	Human pancreatic tissue proteome of type 1 diabetes

nPOD Archived Research Projects

Category	Investigator	Institution	Grant Title
Immunology	Ivana Durinovic-Bello, Thomas Wight & Damien Chaussabel	Benaroya Research Institute	Genetic modification and immunologic checkpoints of proinsulin response
	Jerry Nepom	Benaroya Research Institute at Virginia Mason	TCR repertoire analysis in type 1 diabetes
	Jo Spencer	King's College London School of Medicine	Phenotype, specificity, diversity and clonal spread of ß-cells in type 1 diabetes
	Brad Stone, Bill Kwok & Matthias von Herrath	Benaroya Research Institute	Systematic assessment of autoreactivity in human type 1 diabetes
	Garth Warnock	University of British Columbia	Characterization of T-cell costimulatory molecules in pancreata from IAPCD
Metablic and Development	Hector Deluca	University of Wisconsin	Vitamin D receptor in human insulitic pancreas
	Anna Moore & Amol Kavishwar	Massachusetts General Hospital	In vivo imaging of islets
Pathology	Brad Marsh	University of Queensland, Australia	3D structural characterization of human islet dysfunction/destruction
	Scott Swenson	Yale University	Polyploidy in the exocrine pancreas
Type 1 Diabetes Etilogy	Eric Triplett, Clive Wasserfall & Mark Atkinson	University of Florida	Gut microbiota in early type 1 diabetes
	Ake Sjoholm	Karolinska Institute, Sweden	Ljungan virus in type 1 diabetes patients

Please click here to learn more about our nPOD Investigators