nPOD Abstracts & Oral Presentations

2010

Cheung, S. C., Ou D., Metzger, D. L., Akhoundsadeg,h N., A,o Z., H,e Z., Da,i L., Wan,g X., Ha,o J., Campbell-Thompso,n M., Warnoc,k G. L. (2010). Heterogeneous Expression of B7-H4 and Insulin in Pancreatic Islet  Cells in Patients with Type 1 Diabetes [Abstract no.1342-P]. American Diabetes Association 70th Scientific Sessions.

Myhr, C., Wasserfall, C., Haller, M., Schatz, D., Atkinson, M. (2010). Unique Gene Expression Profiles from Peripheral Blood in Subjects with Type 1 Diabetes [Abstract no.1235-P]. American Diabetes Association 70th Scientific Sessions.

Garrigan, E., Han, Z., Seydel, F., Belkin, N. S., Riggs, C., Amick, M., Cdebaca, A., Pilant, T., Bober, R., Wasserfall, C., Atkinson, M., Clare-Salzler, M. J., Morel, L., McDuffie, M., Literland, S. A. (2010). A Model for Studying the Impact of Nurture on Nature: Development of Diabetes in Multicongenic Mice with an Epigenetic Gene Expression Dysregulation Defect from the Nonobese Diabetic Mouse (NOD) [Abstract no. 1328-P]. American Diabetes Association 70th Scientific Sessions.

Almehthel, M., Paty, B., Warnock, G., Ao, Z., Meloche, M., Keown, P., Shapiro, J., Ho, S., Worsley, D., Fung, M., Meneilly, G., Kondi, J., Alghofaili, K., Kozak, S., Tong, S., Trinh, M., Fensom, B., Kozak, R., Harris, C., Thompson, D. (2010). Variables Affecting C-Peptide Levels after Islet-Cell Transplantation [Abstract no. 2056-P]. American Diabetes Association 70th Scientific Sessions.

Thayer, T. C., Delano, M., Tse, H. M., Piganelli, J. D., Moldawer, L., Mathews, C. E. (2010). Macrophage and T Cell ROS Production Is Critical for T1D Pathogenesis [Abstract no.1350-P]. American Diabetes Association 70th Scientific Sessions.

Haseda, F., Murase-Mishiba, Y., Hirano-Kuwata, S., Terasaki, J., Imagawa, A., Hanafusa, T. (2010). Reduced Expression of Intracellular CTLA-4 in Regulatory T-Cells from Patients with Fulminant Type 1 Diabetes [Abstract no. 1354-P]. American Diabetes Association 70th Scientific Sessions.

Rowe, P., Wasserfall, C., Fernanda-Martino, M., Albanese-O'Neill, A., Schatz, D., Atkinson, M. (2010). Islet Glucagon Staining in Pancreata from Diabetic Organ Donors May Be Inversely Related to In-Vivo-Cell Insulin Function [Abstract no.1735-P]. American Diabetes Association 70th Scientific Sessions.

Michels, A. W., Ostrov, D. A., Zhang, L., Nakayama, M., Atkinson, M., Eisenbarth, G. S. (2010). Identification of Small Molecules That Enhance Anti-Insulin Peptide T Cell Receptor Signaling and IL-10 Secretion [Abstract no. 0335-OR]. American Diabetes Association 70th Scientific Sessions.

Blanton, D., Hong, P., Alexander, J. J., Myhr, C., Han, Z., Wasserfall, C., Schatz, D., Atkinson, M. (2010). QRT-PCR and Custom Immune System Phenotyping Arrays for Characterizing Gene Expression in Type 1 Diabetes [Abstract no. 2411-PO]. American Diabetes Association 70th Scientific Sessions.

Guo, L., Li, W., Pittenger, G., Fishwick-Taylor, D, Vinik, A. I., Bonner-Weir, S. (2010). Pancreatic Regeneration after Partial Pancreatectomy (Px) in Mice Mirrors That in Rats with Both Enhanced Replication and Neogenesis [Abstract no. 2589-PO]. American Diabetes Association 70th Scientific Sessions.

Nishimura, W., Bonner-Weir, S., Sharma, A. (2010). Expression of MafA in Pancreatic Progenitors Maintains Differentiation Potential of Late Embryonic Tubules [Abstract no. 1692-P]. American Diabetes Association 70th Scientific Sessions.

Ouziel-Yahalom, L., Straussman, S., Li, W., Levine, J., Deng, S., Bonner-Weir, S. (2010). Expansion of Pancreatic Duct Cells in Culture Results in Loss of Transcriptional Profile That Favors Neogenesis [Abstract no. 1698-P]. American Diabetes Association 70th Scientific Sessions.

Aguayo-Mazzucato, C., Zavacki, A. M., Larsen, P. R., Hollister-Lock, J., Li, W., Weir, G. C., Sharma, A., Bonner-Weir, S. (2010).Thyroid Hormones Promote MafA-Mediated Maturation of Neonatal Rat-Cells [Abstract no. 1703-P]. American Diabetes Association 70th Scientific Sessions.

Guo, L., Levine, J., Inada, A., Fujitani, Y., Wright, C. V., Bonner-Weir, S. (2010). Duct-Specific Deletion of Pdx1 after Birth Leads to Transient Hyperglycemia [Abstract no. 1704-P]. American Diabetes Association 70th Scientific Sessions.

Keenan, H. A., Sun, J. K., Whelan, L., Geltman, J. A., Aiello, L. P., Bonner-Weir, S., King, G. L. (2010). Pre- and Post-Mortem Demonstration of Persistent-Cell Function and Turnover after More Than 50 Years of Type 1 Diabetes [Abstract no. 0229-OR]. American Diabetes Association 70th Scientific Sessions.

Han, Z., Garrigan, E., Atkinson, M., Wasserfall, C., Clare-Salzler, M. J., Amick, M., Litherland, S. A. (2010). Epigenetic Dysfunction in Autoimmune Diabetes: Persistent Monocyte STAT5 Phosphorylation Promotes Epigenetic Dysregulation of GM-CSF-Induced PGS2/COX2 Expression in Type 1 Diabetes [Abstract no.0217-OR]. American Diabetes Association 70th Scientific Sessions.

Campbell-Thompson, M., Rowe, P. A., Wasserfall, C., Pietras, R., Albanese-O'Neill, A., Gianani, R., Schatz, D. A., Atkinson, M. (2010). Histopathology of Type 1 Diabetes in U.S Organ Donors [Abstract no. 0218-OR]. American Diabetes Association 70th Scientific Sessions.

Wang, C. C., Gunter, J., Leitner J. W., Lu, L., Xu, Y., Greyson, C. R., Gianani, R., Draznin, B., Reusch, J. E., Schwartz, G. C. (2010). Early Defects Occur in PI3-Kinase/Akt Signaling and Vascular Function in a Novel Porcine Model of Diet-Induced Obesity [Abstract no.0249-OR]. American Diabetes Association 70th Scientific Sessions.

Li, C., Hiraoka-Yamamoto, J., Li, Q., Clermont, A., Goodyear, L. J., Kahn, R., King, G. (2010). Diabetes-Like Paradoxical Expression of Vascular Endothelial Growth Factor (VEGF) and Angiogenesis in the Peripheral Tissue and Retina Reproduced in Endothelial Specific PKC2 Overexpression Mice [Abstract no. 0251-OR]. American Diabetes Association 70th Scientific Sessions.

Kondi, J. A., Paty, B., Warnock, G., Ao, Z., Mecloche, M., Keown, P., Shapiro, J., Ho, S., Worsley, D., Fung, M., Meneilly, G., Mehthel, M. L., Alghofaili, K., Kozak, S., Tong, S., Trinh, M., Fensom, B., Kozak, R., Harris, C., Thompson, D. (2010). The Effect of Islet Cell Transplant on Insulin Requirements in Type 1 Diabetess [Abstract no. 2034-P]. American Diabetes Association 70th Scientific Sessions.

Jermendy, A., Vetere, A., Kattabi, I. E., Siniakowicz, K., Bee, Y. M., Aguayo-Mazzucato, C., Sharma, A., Bonner-Weir, S. (2010). MafA Knock-Down Leads to Immature Phenotype in Mature Beta-Cells of Primary Adult Rat Islets [Abstract no. 0458-PP]. American Diabetes Association 70th Scientific Sessions.

Vendrame, F., Pileggi, A., Molano, D., Molina, J., Nepom, G. T., Reijonen, H., Pugliese, A. (2010). A Human GAD-Specific CD4 T-Cell Clone Mediates-and-Cell Destruction In Vivo [Abstract no. 1327-P]. American Diabetes Association 70th Scientific Sessions.

Haddad, N. E., Reijonen, H., Augello, A., Azzi, J., Akiyoshi, T., Moore, R., Salem, K., Sayegh, M., Abdi, R. (2010). Unveiling the Immunomodulatory Role of Peripheral Blood Mesenchymal Stem Cells and Their Potential Implication in Type-1 Diabetes [Abstract no. 1361-P]. American Diabetes Association 70th Scientific Sessions.

Rowe, P., Campbell-Thompson, M., Wasserfall, C., Fernanda-Martino, M., Albanese-O’Neill, A., Atkinson, M., Schatz, D. (2010). Clinical Findings in U.S. Organ Donors with Type 1 Diabetes Mellitus [Astract no. 1321-P]. American Diabetes Association 70th Scientific Sessions.

Parker, M., Wasserfall, C., Xue, S., Campbell-Thompson, M., Mathews, C., Schatz, D., Haller, M., Atkinson, M. (2010). Granulocyte Colony-Stimulating Factor Enhances Both ATG and Anti-CD3 mAb-Mediated Reversal of Type 1 Diabetes in NOD Mice [Abstract no. 0437-PP]. American Diabetes Association 70th Scientific Sessions.

Chen, J., Mathews, C. E. (2010) mt-Nd2a Allele Provides on Type 1 Diabetes (T1D) Resistance at Both the Immune and Cell Levels [Abstract no. 1232-P]. American Diabetes Association 70th Scientific Sessions.

Luzardo, Y., Levine, F., Mathews, C. E.. (2010)Immune Mediators Kill the Human Beta Cell Line lox5 by Apoptosis and Necrosis [Abstract no. 1682-P]. American Diabetes Association 70th Scientific Sessions.

Cheung S. S., Hsu, W. C., Keenan, H., Tsui, T., Okeke, E., King, G. (2010). Variables Affecting C-Peptide Levels after Islet-Cell Transplantation [Abstract no. 2056-P]. American Diabetes Association 70th Scientific Sessions.

Tsutsumi, C., Imagawa, A., Ikegami, H., Makino, H., Kobayashi, T., Hanafusa, T. Res. Comm. of Type 1 Diab. In the Japan Diab. Soc.(2010). Difference in Class II HLA Haplotype within Fulminant Type 1 Diabetes with or without GAD Antibodies [Abstract no. 1231-P]. American Diabetes Association 70th Scientific Sessions.

Gottlieb, P., Colman, P. G., Solvason, N., Otto, K., Roep, B., Harrison, L. C., Eisenbarth, G., Robinson, W., Utz, P. J., Steinman, L., Garren, H., Quan, J. (2010). One-Year Results from a Phase 1/2 Clinical Trial of BHT-3021, a DNA Plasmid Vaccine for Type 1 Diabetes (T1D) [Abstract no. 0066-OR ]. American Diabetes Association 70th Scientific Sessions.

Ouziel-Yahalom, L., Li, W., Straussman, S., Guo, L., Sharma, A., Weir, G. C., Bonner-Weir, S. (2010). Ductal Heterogeneity Suggests a Subpopulation Serves as Postnatal Pancreatic Progenitors [Abstract no. 0091-OR]. American Diabetes Association 70th Scientific Sessions.

Thompson, D. M., Ao, Z., Paty, B., Meloche, M., Keown, P., Shapiro, J., Ho, S., Worsley, D., Meneilly, G., Mehthel, M. A., Alghofaili, K., Fung, M., Kondi, J., Kozak, S., Tong, S., Trinh, M., Fensom, B., Kozak, R., Harris, C., Warnock, G. (2010). Comparison of Islet Cell Transplantation with Intensive Medical Therapy on the Rate of Decline in Glomerular Filtration Rate in Patients with Type 1 Diabetes [Abstract no. 0137-OR ]. American Diabetes Association 70th Scientific Sessions.

Campbell, M. S., Thayer, T. C., Liu, C., Pliner, V., Mathews, C. E. (2010). Suppressor of Superoxide Production - Locus Dominantly Prevents T1D as Well as Insulitis and Maps to Ankrd50[Abstract no. 0130-OR]. American Diabetes Association 70th Scientific Sessions.

2009

Gianani, R., Campbell-Thompson, M., West, E., Seaman, S., Kent, S.C., Hering, B., Pugliese, A., Sarkar, S., Eisenbarth, G.S., & Atkinson, M. (2009). Pathological heterogeneity of type 1 diabetes [Abstract no. 116]. 10th International Congress of the Immunology of Diabetes Society.

Kent, S.C., Bradshaw, E.M., Hang, Q., Varadarajan, N., Greer, A., Love, J.C., & Hafler, D.A. (2009). Autoreactive B cells in pancreatic draining lymph nodes from type 1 diabetes subjects [Abstract no. 126]. 10th International Congress of the Immunology of Diabetes Society.

Tauriainen, S., Oikarinen, M., Keim, J., Oikarinen, S., Hyoty, H., & nPOD Study Group. (2009). Detection of enterovirus in pancreatic tissues of cadaver organ donors -- results from the Network for Pancreatic Organ Donors with Diabetes (nPOD) Study [Abstract no. 155]. 10th International Congress of the Immunology of Diabetes Society.

Gianani, R. (2009, June 6) Dimorphic Histopathology of Long Standing Childhood Diabetes (70-OR). Paper presented at the American Diabetes Associations 69th Scientific Sessions, New Orleans, LA.

Yip, L., Su, L., Creusot, R.J., Sheng, D., Chang, P., Atkinson, M., Albert, P.R., Turley, S.J., & Fathman, C.G. (2009). Deaf1 isoforms control changes in peripheral tissue antigen gene expression in the NOD mouse pancreatic lymph node during type 1 diabetes pathogenesis [Abstract no. 75]. 10th International Congress of the Immunology of Diabetes Society.

Gianani, R., Thompson, M.C., Wasserfall, C., Pugliese, A., Kent, S., Hering, B., West, E., Steck, A., Bonner-Weir, S., Eisenbarth, G., Atkinson, M. (2009) Dimorphic Histopathology of Longstanding Childhood Diabetes [Abstract no. 70-OR]. American Diabetes Association 69th Scientific Sessions.

Keenan, H.A., Sun, J.K., Bonner-Weir, S., Whelan, L., Geltman, J., Aiello, L.P., King, G.L. (2009) Physiological and Histological Demonstration of Residual Pancreatic β Cells after 50 Years of Type 1 Diabetes [Abstract no. 1462-P]. American Diabetes Association 69th Scientific Sessions.

Rowe, P.A., Campbell-Thompson, M., Wasserfall, C.H., Martino, M.F., Albanese-O'Neil, A., Schatz, D., Atkinson, M. (2009) Network for Pancreatic Organ Donors with Type 1 Diabetes (nPOD): Progress and Donor Demographics [Abstract no. 1593-P]. American Diabetes Association 69th Scientific Sessions.