Our scientists are not locatedin one lab,on one campus,or in one country…
We are united in one goal, to cure type 1 diabetes.
Marika Bogdani, Pamela Y. Johnson, Susan Potter-Perigo, Nadine Nagy, Anthony J. Day, Paul L. Bollyky, and Thomas N. Wight (2014) Hyaluronan and Hyaluronan Binding Proteins Accumulate in both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate with Inflammatory Cells in Insulitis. Diabetes Published online before print March 27, 2014, doi: 10.2337/db13-1658 Diabetes, March 27, 2014
Dotta F, Sebastiani G. (2014). Enteroviral infections and development of type 1 diabetes: The Brothers Karamazov within the CVBs. Diabetes. Feb;63(2):384-6. doi: 10.2337/db13-1441.
Exeter slides now available
nPOD Online Pathology Database has obtained scanned images from slides used in an insulitis workshop held in Exeter, UK, November 2013. A group of premier pathologists and investigators (Mark Atkinson, Alex Butler, Martha Campbell-Thompson, Francesco Dotta, Alan Foulis, Peter In’t Veld, Günter Klöppel, Ed Leiter, Noel Morgan and Sarah Richardson) met to review histopathological characteristics of insulitis in human type 1 diabetes in light of a recent consensus statement on insulitis . Representative scanned slides from patients at disease onset were compared to those in the nPOD biobank from recent onset organ donors with type 1 diabetes. These slides are very precious and some are dated way back from 1930s [2-8]. Once you login onto nPOD Online Pathology, you can find six Exeter folders organized by submitter. To request access to nPOD Online Pathology, please visit Online Pathology Info page.
Availability of Retired Cases for Assay Validation and Generation of Preliminary Data
The JDRF nPOD has now available a couple of cases that have been retired for distribution to research projects, but can be used for assay validation or generation of preliminary data. Reasonable amounts of materials can be requested, using the tissue request form. These specimens are available to approved nPOD investigators and to investigators who do not yet have a project approved by nPOD. For example, such specimens could be used to validate an antibody stain in human pancreas, when the investigator has not yet examined human tissues. When requesting such tissues, please provide a short justification and specify quantities, again using the tissue request form is preferable.
(Universitet Libre de Bruxelles, Brussels, Belgium)
The JDRF-nPOD Scientists Who Seek the Cure for T1D
Each month, we highlight one of the nPOD investigators. Thanks to the fundraising of all the JDRF chapters, these scientists are able to have access to nPOD samples for their work. We’ll let them introduce themselves, tell you about their research, and their lives.